6533b872fe1ef96bd12d30c4
RESEARCH PRODUCT
Characteristics of Bipolar Patients with Cognitive Impairment of Suspected Neurodegenerative Origin: A Multicenter Cohort
Emilie OliéEmmanuel CognatDjamila BennabiEsteban Munoz MusatFrédéric BlancFlorence LebertEloi MagninAudrey GabelleClaire PaquetMélanie LeroyEmeline Marlingesubject
cognitionmedicine.medical_specialty[SDV]Life Sciences [q-bio]Medicine (miscellaneous)ParkinsonismArticleInternal medicinemedicineDementiaBipolar disorderbipolar disorderbusiness.industryParkinsonismneurodegenerescenceNeuropsychologyRbiomarkersCognitionmedicine.disease[SDV] Life Sciences [q-bio]Biomarker (medicine)MedicinebusinessNeurocognitiveAlzheimer’s diseaseExecutive dysfunctiondementiadescription
Bipolar disorder is associated with an increased risk of dementia with aging. Little is known regarding this association, limiting appropriate diagnosis and management. We aimed to describe the characteristics of bipolar patients with late cognitive impairment for whom the hypothesis of an underlying neurodegenerative disease had been raised. We performed a retrospective multicenter study, recruiting bipolar patients over 50 years old from five French tertiary memory centers who had undergone cerebrospinal fluid (CSF) biomarker assessment for Alzheimer’s disease (AD). Clinical, neuropsychological, and paraclinical characteristics were analyzed and 78 patients were included. The mean age at the onset of cognitive impairment was 62.4 years (±9.2). The mean MMSE score was 22.8 (±4.5), the mean FAB was 11.7 (±3.9), and the mean FCRST was 15.8 (±7.4)/36.8 (±9.7) (free/total recall). A total of 48.6% of the patients displayed cognitive fluctuations, and 38.2% showed cognitive improvement during follow-ups
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-01 |