6533b872fe1ef96bd12d36a9
RESEARCH PRODUCT
�ber die Wirkung von Metyrapon auf den mikrosomalen Arzneimittelabbau
K. J. NetterK. KajuschkeSigrid Jennersubject
PharmacologyMetyraponeChemistryStereochemistrymedicine.medical_treatmentGeneral MedicineOxidative phosphorylationIn vitroSteroidHydroxylationchemistry.chemical_compoundIn vivomedicineMicrosomeAcetanilidemedicine.drugdescription
The inhibitor of adrenal steroid-11-β-hydroxylation, Metyrapone (SU 4885), also decreases the rate of drug hydroxylation reactions, both in vitro and in vivo. The follwing oxidative microsomal reactions were studied: O-demethylation of p-nitroanisole, N-demethylation of amidopyrine, and ring hydroxylation of acetanilide. In all three cases Metyrapone inhibits the formation of the reaction products. The inhibitor concentrations required for reduction of the initial reaction rates to one half are 7.5 · 10−4 M, 5 · 10−4m and 20 · 10−4 M, respectively. Steroid C-11-β-hydroxylation is reduced to one half by 2.5 · 10−4 M Metyrapone.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1967-01-01 | Naunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie |