6533b872fe1ef96bd12d3900
RESEARCH PRODUCT
Interleukin-4 induces secretion of CSF for granulocytes and CSF for macrophages by peripheral blood monocytes.
Wolfgang OsterAlbrecht LindemannR. BoniferFriedhelm HerrmannRoland MertelsmannM. Wiesersubject
Transcription GeneticT cellImmunologyBiologyBiochemistryMonocytesColony-Forming Units AssayMiceColony-Stimulating FactorsGranulocyte Colony-Stimulating FactormedicineBioassayAnimalsHumansInducerSecretionNorthern blotInterleukin 4Mice Inbred C3HMonocyteInterleukinsMacrophage Colony-Stimulating FactorMacrophagesCell BiologyHematologyMolecular biologyPeripheral bloodRecombinant Proteinsmedicine.anatomical_structureImmunologyInterleukin-4Granulocytesdescription
Abstract T cells are known to interact cooperatively with monocytes to produce Colony-Stimulating Factors (CSF), although T cell-mediated signals leading to CSF secretion by monocytes are not completely understood. We have made use of Northern blot hybridization and specific bioassays to study the effects of the T cell product interleukin-4 (IL-4) on monocyte CSF expression. The results suggest a previously unrecognized role of IL-4 as a CSF inducer since exposure of monocytes to IL-4 resulted in accumulation of transcripts for granulocyte-CSF (G-CSF) and macrophage-CSF (M-CSF). Consequently, IL-4-activated monocytes released factors in their culture supernatants biologically and antigenically indistinguishable from G- and M-CSF.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-04-01 | Blood |