6533b872fe1ef96bd12d3a71

RESEARCH PRODUCT

Cytoprotective organoselenium compounds for oligodendrocytes

Dominique Vervandier-fasseurHany ElsawyHany ElsawyIsmail AlthagafiMustapha Cherkaoui-malkiAmira ZarroukAmira ZarroukYasair S.s. Al-faiyzSaad ShaabanSaad ShaabanPierre Andreoletti

subject

AntioxidantCytoprotectiveGeneral Chemical Engineeringmedicine.medical_treatmentOrganoselenium02 engineering and technology010402 general chemistry01 natural sciencesRedoxlcsh:Chemistrychemistry.chemical_compoundOrganoselenium CompoundmedicineTetrazoleCytotoxicityTetrazoleOligodendrocytesGeneral Chemistry021001 nanoscience & nanotechnologyCombinatorial chemistry0104 chemical sciencesUgi reactionchemistrylcsh:QD1-999Antioxidant0210 nano-technology

description

Abstract Herein we report the synthesis of peptide-like and tetrazole-based organoselenium compounds via Ugi and Ugi-azide reactions, respectively. The organoselenium compounds' intrinsic cytoprotective and antioxidant capacities were evaluated in 158 N and 158JP murine oligodendrocytes. Furthermore, their redox properties were theoretically evaluated using Molecular Operating Environment-docking studies. Most of the compounds did not exhibit any cytotoxicity against the 158JP and 158 N cells. Among the tested compounds, the tetrazole- (e.g., 6, 7, and 9) and the pseudopeptide-based organoselenium compounds (e.g., 11, 15, and 17) displayed antioxidant properties. On the other hand, the quinones- (e.g., 4c and 18) and the pseudopeptides-based (e.g., 12, 14, and 17) organoselenium compounds exhibited prooxidant activities. Furthermore, the tetrazole-based organoselenium compounds 5 and 9 and the selenopeptide 11 and 15 showed good GPx-like activity. Some of the newly synthesized organoselenium compounds presented interesting antioxidant and cytoprotective activities and are therefore considered potential myelin diseases drug candidates.

10.1016/j.arabjc.2021.103051http://www.sciencedirect.com/science/article/pii/S1878535221000666