6533b872fe1ef96bd12d3abc
RESEARCH PRODUCT
Gender-Specific Metabolomics Approach to Kidney Cancer
Piotr MłynarzAdam LitarskiWojciech WojtowiczAdam ZabekStanislaw DejaStanislaw DejaNatalia Pudełko-malikTomasz SzydełkoKarolina Anna Mielkosubject
medicine.medical_specialtyrenal cell carcinomaEndocrinology Diabetes and MetabolismPhysiologyMalignancyurologic and male genital diseasesBiochemistryMicrobiologyArticlechemistry.chemical_compoundMetabolomicsmaleRenal cell carcinomaEpidemiologymedicinegenderCholineMolecular BiologyneoplasmsKidneybusiness.industryIncidence (epidemiology)medicine.diseaseRCCmetabolomicsQR1-502female genital diseases and pregnancy complicationsNMRmedicine.anatomical_structurefemalechemistrybusinessKidney cancerserumdescription
Renal cell carcinoma (RCC) is the most common form of kidney malignancy. RCC is more common among men with a 2/1 male/female incidence ratio worldwide. Given the underlying epidemiological differences in the RCC incidence between males and females, we explored the gender specific 1H NMR serum metabolic profiles of RCC patients and their matched controls. A number of differential metabolites were shared by male and female RCC patients. These RCC specific changes included lower lactate, threonine, histidine, and choline levels together with increased levels of pyruvate, N-acetylated glycoproteins, beta-hydroxybutyrate, acetoacetate, and lysine. Additionally, serum lactate/pyruvate ratio was a strong predictor of RCC status regardless of gender. Although only moderate changes in metabolic profiles were observed between control males and females there were substantial gender related differences among RCC patients. Gender specific metabolic features associated with RCC status were identified suggesting that different metabolic panels could be leveraged for a more precise diagnostic.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-10 | Metabolites |