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RESEARCH PRODUCT
Molecular Histochemistry of Nicotinic Receptors in Human Brain
Hannsjörg SchröderUlrich SchützRob A.i. De VosEzio GiacobiniNatasha MoserGerard Van NoortElke HappichE. N. H. JansenAndrea WeversAlfred Maelickesubject
Nicotinic Receptorsmusculoskeletal neural and ocular physiologyHuman brainBiologyNicotinic acetylcholine receptormedicine.anatomical_structureNicotinic agonistnervous systemmedicineImmunohistochemistrysense organsSignal transductionReceptorNeuroscienceAcetylcholine receptordescription
Only a decade ago the existence and functional significance of central nervous nicotinic acetylcholine receptors (nAChR) was still a subject of controversy. Today, the importance of this receptor class for signal transduction in human brain in normal and pathological conditions has become quite evident. nAChRs have turned out to be important pharmacological targets in disorders like Alzheimer’s disease (AD) (Arneric et al., 1994). One prerequisite to understand nAChR function is a detailed study of the cellular distribution of nAChR subtypes. In recent years several human-specific data have been made available. This paper attempts to show actual developments in this field, summarizing the expression and localization of nAChRs in human development, age and neurodegenerative states.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-01-01 |