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RESEARCH PRODUCT

Copper Complexes with Sulfonamides Derivatives of Natural Amino Acids as Chemical Nucleases

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Three new coordination compounds have been prepared by reacting copper salts with sulfonamides derived from amino acids. Their molecular structures have been determined with the aid of single crystal X-ray diffraction. The copper cations are four-coordinated in all cases and the local environment is almost planar. Compound [Cu(ts-gly)(NH3)2]·H2O (1) crystallizes in monoclinic space group P21/c (no 14) with Z = 4 and with unit cell parameters a = 6.0490(12) A, b = 24.719(5) A, c = 9.159(2) A, α = γ = 90°, and β = 94.69(3)°. Compound [Cu(ts-isoleu)(NH3)2] (2) crystallizes in monoclinic space group C2/c (no 8) with Z = 15 and with unit cell parameters a = 30.800(6) A, b = 6.5510(13) A, c = 15.830(3) A, α = γ = 90°, and β = 100.19(3)°. Compound Na[Cu(ts-gly)(gly)]·2H2O (3) crystallizes in triclinic space group P-1 (no 2) with Z = 2 and with unit cell parameters a = 5.6220(11) A, b = 7.775(2) A, c = 18.704(4) A, α = 94.61(3)°, β = 98.32(3)°, and γ = 98.29(3)°. The study of nuclease activity with plasmid pUC18 shows that all three compounds act as chemical nucleases, although complex Na[Cu(ts-gly)(gly)]·2H2O is more efficient in splitting the DNA chains than the other two compounds.