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RESEARCH PRODUCT
High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction
Claudia KorandjiMarianne ZellerAline ChagnonClaude TouzeryYves CottinJulie LorinCatherine Vergely Jean-claude GuillandFlorence BichatLuc Rochettesubject
MaleArginineEpidemiologyMyocardial Infarctionlcsh:Medicine030204 cardiovascular system & hematologyCardiovascularBiochemistrychemistry.chemical_compound0302 clinical medicineMedicineMyocardial infarctionlcsh:ScienceChromatography High Pressure Liquid0303 health sciencesMultidisciplinarybiologyNeurochemistryMiddle Aged[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system3. Good healthNitric oxide synthaseBlood ChemistryMedicinelipids (amino acids peptides and proteins)FemaleNeurochemicalsLipoproteins HDLResearch Articlemedicine.medical_specialtyClinical Research DesignLipoproteinsNitric OxideArginineNitric oxide03 medical and health sciences[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineHumansBiologyCardiovascular Disease Epidemiology030304 developmental biologyAgedPopulation Biologybusiness.industryCholesterollcsh:RProteinsmedicine.diseaseBioavailabilityBiomarker EpidemiologyEndocrinologychemistrybiology.proteinlcsh:QbusinessAsymmetric dimethylarginineLipoproteinNeurosciencedescription
International audience; Objectives: Low levels of high-density lipoprotein (HDL) cholesterol are associated with an increased risk of acute myocardial infarction possibly through impaired endothelial atheroprotection and decreased nitric oxide (NO) bioavailability. Asymmetric dimethylarginine (ADMA) mediates endothelial function by inhibiting nitric oxide synthase activity. In patients with acute myocardial infarction, we investigated the relationship between serum levels of HDL and ADMA. Approach and Results: Blood samples from 612 consecutive patients hospitalized for acute MI ,24 hours after symptom onset were taken on admission. Serum levels of ADMA, its stereoisomer, symmetric dimethylarginine (SDMA) and L-arginine were determined using high-performance liquid chromatography. Patients with low HDL (,40 mg/dL for men and ,50 mg/dL for women) were compared with patients with higher HDL. Most patients (59%) had low HDL levels. Median ADMA levels were markedly higher in the low HDL group (0.69 vs. 0.50 mmole/L, p,0.001). In contrast, SDMA and L-arginine levels were similar for the two groups (p = 0.120 and p = 0.064). Notably, ADMA, but not SDMA or L-arginine, was inversely correlated with HDL (r = 20.311, p,0.001). In stratified analysis, this relationship was only found for low HDL levels (r = 20.265, p,0.001), but not when HDL levels were higher (r = 20.077, p = 0.225). By multivariate logistic regression analysis, ADMA level was strongly associated with low HDL levels (OR(95%CI):6.06(3.48-10.53), p,0.001), beyond traditional confounding factors. Conclusions: Our large population-based study showed for the first time a strong inverse relationship between HDL and ADMA in myocardial infarction patients, suggesting a functional interaction between HDL and endothelium, beyond metabolic conditions associated with low HDL levels.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-06-06 | PLoS ONE |