6533b872fe1ef96bd12d431b
RESEARCH PRODUCT
Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?
Sönke DetlefsenMorten KarsdalAleksander KragAleksander KragDetlef SchuppanDetlef SchuppanMette Juul NielsenSamuel Joseph Danielssubject
Liver Cirrhosis0303 health sciencesPathologymedicine.medical_specialtyHepatologybusiness.industryLiver fibrosismedicine.diseaseFatty Liver03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesismedicineAnimalsHumansCollagenSteatohepatitisbusiness030304 developmental biologydescription
Is liver fibrosis just liver fibrosis? Or do the subtype of collagen, its spatial localization in the liver, its cell of origin, and the time point at which it is synthesized also matter? It is important, since the various collagen subtypes hold different informative values regarding reparative processes in the liver, and as collagens have also emerged as important signaling molecules (1). Novel data have challenged our perception of liver fibrosis and collagens, which may have important implications regarding the development of new biomarkers and anti-fibrotic interventions. The traditional histological analysis of liver biopsies using histochemical collagen stains, such as the Masson's Trichrome stain or the Sirius Red stain, group all triple helical collagen structures into one gross bucket. Importantly, these stains ignore many other quantitatively minor but nonetheless functionally and structurally relevant collagen and non-collagen extracellular matrix (ECM) components.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |