6533b872fe1ef96bd12d4329
RESEARCH PRODUCT
Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa.
Adriana BasileNicola MascoloCarmen FormisanoAntonella MaggioGabriella BelloneSergio RosselliMaurizio BrunoCarla CicalaAlessio Alfierisubject
MalePharmaceutical ScienceCitroptenFlowersMicrobial Sensitivity TestsPharmacognosyAnalytical Chemistrychemistry.chemical_compoundCoumarinsDrug DiscoveryOrganic chemistryAnimalsRats WistarAntibacterial agentPharmacologyApiaceaebiologyTraditional medicineImperatorinOrganic ChemistryAnticoagulantsbiology.organism_classificationAnti-Bacterial AgentsRatsComplementary and alternative medicinechemistryPhytochemicalMolecular MedicineAntibacterial activityOstholApiaceaedescription
The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between 16 and 256 microg/mL), the most active being imperatorin (3) (MICs between 32 and 128 microg/mL) and citropten (4) (MICs between 16 and 256 microg/mL). The anticoagulant activity of compounds 1-4 and 7 was also evaluated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-11-28 | Planta medica |