6533b873fe1ef96bd12d4b25
RESEARCH PRODUCT
Crosslinked α,β-Polyasparthydrazide Micromatrices for Controlled Release of Anticancer Drugs
Bianca CarlisiGennara CavallaroGiovanna PitarresiGaetano Giammonasubject
Polymers and Plastics0206 medical engineeringBioengineeringmacromolecular substances02 engineering and technologyBiomaterialschemistry.chemical_compoundPolymer chemistryMaterials ChemistrymedicineDissolutionchemistry.chemical_classificationtechnology industry and agriculturePolymerBuffer solution021001 nanoscience & nanotechnology020601 biomedical engineeringControlled releaseIn vitrochemistrySelf-healing hydrogelsGlutaraldehydeSwellingmedicine.symptom0210 nano-technologyNuclear chemistrydescription
The preparation of new hydrogels by the reaction of α,β- polyasparthydrazide and glutaraldehyde is reported. A different crosslinking degree was obtained by varying the ratio crosslinking agent/polymer which influenced the swelling behavior of the gel. 5-Fluorouracil, was incorporated into the matrices during the crosslinking reaction and in vitro release studies were performed in simulated gastric juice (pH 1.1) and pH 7.4 buffer solution. The hydrogels prepared were chemically stable in the dissolution media. The observed data show the potential application of these new matrices for peroral administration of anticancer agents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-01-01 | Journal of Bioactive and Compatible Polymers |