6533b873fe1ef96bd12d4b7e
RESEARCH PRODUCT
Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions
Amaia RodríguezAmaia RodríguezLourdes Garrido-sánchezLourdes Garrido-sánchezFrancisco J. TinahonesFrancisco J. TinahonesAna B CrujeirasFelipe F. CasanuevaRosa M. BañosRosa M. BañosRoser GraneroRoser GraneroSarah SauchelliGema FrühbeckGema FrühbeckJosé Manuel Fernández-realFernando Fernández-arandaFernando Fernández-arandaCristina BotellaSusana Jiménez-murciaSusana Jiménez-murciaRafael De La TorreRafael De La TorreJosé Carlos Fernández-garcíaJosé Carlos Fernández-garcíaFrancisco J. OrtegaStephan ZipfelJosé M. MenchónKatrin Elisabeth Gielsubject
Gerontologymedicine.medical_specialtybusiness.industry030209 endocrinology & metabolismmedicine.diseaseSleep in non-human animalsObesityPittsburgh Sleep Quality Index03 medical and health sciencesPsychiatry and Mental healthClinical PsychologyEating disorders0302 clinical medicineInternal medicinemedicineAnxietymedicine.symptombusinessBody mass indexSomatization030217 neurology & neurosurgeryPsychopathologydescription
The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p =.050), greater depression, anxiety and somatization symptoms (all: p <.001), and impoverished self-reported sleep quality (p <.001). A quadratic trend was found in objective sleep time, being longest in the obese group (p =.031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-10-26 | European Eating Disorders Review |