6533b873fe1ef96bd12d4b83
RESEARCH PRODUCT
The behaviour of 2-nitrothiophene and of 3-nitrothiophene with some nucleophiles
Domenico SpinelliM. NoviGiuseppe GuantiC. Dell’erbasubject
chemistry.chemical_compoundNucleophileChemistryOrganic ChemistryOrganic chemistryReactivity (chemistry)PiperidineMedicinal chemistrydescription
The reactivity of 2-nitrothiophene (1) and of 3-nitrothiophene (II) with some nucleophiles has been studied. According to calculated electronic densities I can receive nucleophilic attack at C3 and C5 depending on the nucleophile used, but II only at C2. With N-lithium piperidine both I and II also give coupling products (VII and XI respectively) of the hithienyl type.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1975-04-01 | Journal of Heterocyclic Chemistry |