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RESEARCH PRODUCT
The Ionic Hypothesis of Aging
Mario BarbagalloLigia J. DominguezMaria Adele AlessiLawrence M. ResnickAnna LicataGiuseppe LicataLilia Granvillanosubject
medicine.medical_specialtyMechanism (biology)business.industrymedicine.diseaseLeft ventricular hypertrophyEssential hypertensionObesitychemistry.chemical_compoundInsulin resistanceEndocrinologyDehydroepiandrosterone sulfatechemistryInternal medicineDiabetes mellitusmedicineHyperinsulinemiabusinessdescription
The clinical association of essential hypertension with metabolic abnormalities, such as hyperinsulinemia, insulin resistance, obesity, altered glucose tolerance and/or frank non-insulin dependent diabetes mellitus (NIDDM) has long been appreciated(1). Each of the above clinical conditions is extremely frequent in the elderly. The association of these different clinical states, that is also common at younger ages, has been termed “Syndrome X” and more recently “Generalized Cardiovascular-Metabolic Disease.”(2,3) Although several hypothesis have been proposed, including a primary role of hyperinsulinemia and insulin resistance, the mechanism(s) of this linkage has not been established. This syndrome complex is frequently associated with target organ involvement, such as left ventricular hypertrophy (LVH) and atherosclerosis of the coronary and peripheral vascular beds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-01-01 |