6533b873fe1ef96bd12d4bef
RESEARCH PRODUCT
New cytostatic agents obtained by molecular topology
Jorge GalvezM.j. Gomez-lechónRamón García-domenechJ.v. Castellsubject
Carminic acidOrganic ChemistryClinical BiochemistryCytostatic agentsPharmaceutical ScienceComputational biologyPharmacologyPiromidic acidBiochemistrychemistry.chemical_compoundAntibiotic AgentschemistryDrug DiscoverymedicineMolecular MedicineMolecular topologyMolecular Biologymedicine.drugdescription
Abstract Four new cytostatic compounds have been obtained by computer aided selection based on Molecular Connectivity, a topological approach to molecular structural study. Three of them, namely tetracycline, doxycycline and piromidic acid are well known antibiotic agents, and the fourth, carminic acid, is an innocuous colorant. Although no previous report of activity was found, on the used cell lines, for any of the selected compounds, carminic acid may be considered a new lead one since no structure-related cytostatic molecules have been reported in the literature. These results are interesting for two reasons: First, new potential low-toxicity anticancer drugs show to be a possible therapy, and second, the usefulness of our topological approach in evaluating pharmacological mechanisms of action, already demonstrated in the search for other therapeutical agents, is confirmed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-10-01 | Bioorganic & Medicinal Chemistry Letters |