6533b873fe1ef96bd12d4c8b
RESEARCH PRODUCT
Foetal erythrocytes exhibit an increased ability to scavenge for nitric oxide
Juan V. EspluguesSara CalatayudJuan BrinesSalvador MoncadaBelén Beltránsubject
Adultmedicine.medical_specialtyErythrocyteshaemoglobin foetalVasodilationIn Vitro TechniquesNitric OxideNitric oxidechemistry.chemical_compoundnewbornInternal medicinemedicineAnimalsHumansnitric oxide (NO)Aortavascular responseWhole bloodPharmacologyDose-Response Relationship DrugPenicillamineSnapAnatomyFetal BloodRatsRed blood cellEndocrinologymedicine.anatomical_structurechemistryVasoconstrictionCirculatory systemembryonic structuresHemoglobinerythrocyteBlood vesseldescription
The presence of adult human whole blood inhibited in vitro relaxations of rat aortic rings by the nitric oxide (NO) donor S-nitroso-N-acetyl-DL-penicillamine (SNAP). Incubation with foetal blood containing the same concentration of haemoglobin produced a shift to the right of the relaxation curve. SNAP-induced vasorelaxations were more inhibited by dialysed solutions of haemoglobin than by the presence of erythrocytes in the organ bath, but there were no differences between the effect of adult or foetal haemoglobins. The presence of plasma from adult or foetal blood did not modify the effects of SNAP. Relaxations induced by endogenous, endothelium-derived, NO were more inhibited by foetal than by adult erythrocytes. These results suggest that foetal erythrocytes have a higher NO scavenging effect than those present in adult blood. (C) 1998 Elsevier Science B.V.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-04-01 |