6533b873fe1ef96bd12d4d09
RESEARCH PRODUCT
Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients
Isabelle SimoneauMarie-claude BrindisiAlexia RoulandPauline LegrisBruno VergèsS. Baillot-rudoniLaurence DuvillardBenjamin BouilletJean-michel Petitsubject
Maleendocrine system diseasesEndocrinology Diabetes and MetabolismType 2 diabetesObesechemistry.chemical_compound0302 clinical medicineProspective Studies2. Zero hunger[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismeducation.field_of_studyDiabetesGeneral MedicineArticles[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismMiddle AgedMagnetic Resonance ImagingFructosamineClinical Science and Care030220 oncology & carcinogenesisFructosamineFemalemedicine.medical_specialtyPopulationShort ReportAbdominal Fat030209 endocrinology & metabolismDiseases of the endocrine glands. Clinical endocrinologyFat mass03 medical and health sciencesDiabetes mellitusInternal medicineInternal MedicinemedicineHumansObesityeducationAgedGlycated Hemoglobinbusiness.industrynutritional and metabolic diseasesmedicine.diseaseRC648-665ObesityEndocrinologychemistryDiabetes Mellitus Type 2Glycated hemoglobinbusinessBody mass indexdescription
Abstract Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat mass and fat distribution has never been studied. We studied 112 type 2 diabetes patients with assessment of fat mass, liver fat and fat distribution. Patients with body mass index (BMI) above the median (34.9 kg/m2), versus BMI below the median, had a correlation coefficient between fructosamine and HbA1c significantly reduced (r = 0.358 vs r = 0.765). In the whole population, fructosamine was correlated negatively with BMI and fat mass. In multivariate analysis, fructosamine was associated with HbA1c (positively) and fat mass (negatively), but not with BMI, liver fat or fat distribution. The association between fructosamine and HbA1c is significantly reduced in the most obese type 2 diabetes patients, and this is mostly driven by increased fat mass.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-01 | Journal of Diabetes Investigation |