6533b873fe1ef96bd12d4d6b
RESEARCH PRODUCT
The Endometrial Microbiome and Its Impact on Human Conception
Carlos SimonInmaculada Moreno GimenoBruno Tosonsubject
QH301-705.5microbiomeReviewCatalysisInorganic ChemistryEndometriumreproductive tract microbiotaPregnancyHumansPhysical and Theoretical ChemistryBiology (General)Molecular BiologyQD1-999Spectroscopyendometrial microbiotaassisted reproductive technologiesVirulenceuterusMicrobiotaOrganic ChemistryPregnancy Outcomehuman reproductionGeneral MedicineComputer Science ApplicationsChemistryreproductive outcomesFertilizationDysbiosisFemaleinfertilitydescription
Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-30 | International Journal of Molecular Sciences |