6533b873fe1ef96bd12d4d79
RESEARCH PRODUCT
Electrophysiological evidence for circadian rhythmicity in a mammalian pineal organ
Lutz VollrathP Semmsubject
MaleNeuronsmedicine.medical_specialtyCell typeLightGuinea PigsLow activityDarknessBiologyPineal GlandCircadian RhythmPsychiatry and Mental healthElectrophysiologyPineal glandEndocrinologymedicine.anatomical_structureNeurologyInternal medicineDarknessmedicineAnimalsNeurology (clinical)Circadian rhythmPineal organBiological Psychiatrydescription
Long-term electrophysiological recordings from the guinea-pig pineal organ show that three types of intrinsic cells can be distinguished: (i) Cells showing constant firing rates over periods of up to 24 hours. (ii) Cells which are highly active during the day and show a low firing rate during the night. (iii) Cells which exhibit low activity during the day and enhanced activity during the night; these cells can be strongly inhibited by 1 min of light given during the night. Both the light- and darkness-activated cells show activity patterns which closely follow season-dependent differences in day- and night-lengths. In addition, both cell types show an oscillatory pattern in maintained activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-09-01 | Journal of Neural Transmission |