Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

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RESEARCH PRODUCT

Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

Miligi L Benvenuti A Salvan A Tozzi Ga Ranucci A Legittimo P Bisanti L Zambon P Cannizzaro S Kirchmayer U Cocco P Celentano E Assennato G Merlo Df Mosciatti P Minelli L Cuttini M Torregrossa V Lagorio S Haupt R Risica S Polichetti A Setil Working Group Magnani C.Stefano Mattioli Roberto Rondelli

subject

Male Toxicology Economica Pregnancy hemic and lymphatic diseases Epidemiology Child Multivariate Analysi parental exposure Incidence Lymphoma Non-Hodgkin Incidence (epidemiology)Precursor Cell Lymphoblastic Leukemia-Lymphoma Occupational exposure Epidemiologic Studie Italy Maternal Exposure Chemical Industry Child Preschool Prenatal Exposure Delayed Effects Solvent Paternal Exposure Female Survival Analysi HYDROCARBONS Case-Control Studie Risk assessment Human medicine.medical_specialty Logistic Model Adolescent Socio-culturale Context (language use)Risk Assessment Prenatal Exposure Delayed Effect Hazardous Substances Age Distribution Environmental health medicine Humans Sex Distribution Survival analysis ACUTE LYMPHOBLASTIC-LEUKEMIA business.industry Public Health Environmental and Occupational Health Case-control study Ambientale medicine.disease Survival Analysis Non-Hodgkin's lymphoma Epidemiologic Studies Paternal Exposure Logistic Models solvents Hazardous Substance Case-Control Studies Multivariate Analysis business

description

AIM: In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. METHODS: All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. RESULTS: 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.7) and mineral oils (OR 1.4)[corrected]. Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). CONCLUSIONS: We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.

year	journal	country	edition	language
2013-01-01	Occupational and Environmental Medicine

https://doi.org/10.1136/oemed-2012-100951