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RESEARCH PRODUCT
Toll-like receptors – sentries in the B-cell response
Gaëtan JegoIsabelle Bekeredjian-dingsubject
ImmunologyAntigen presentationReview ArticleBiologyImmunoglobulin secretionImmunomodulationMicemedicineImmunology and AllergyAnimalsHumansReceptorB cellB-LymphocytesInnate immune systemToll-Like ReceptorsImmunoglobulin Class SwitchingImmunity InnateCell biologymedicine.anatomical_structureImmunoglobulin class switchingImmunologyAntibody FormationHost-Pathogen InteractionsCytokine secretionFunction (biology)description
Summary Toll-like receptors (TLR) play a central role in the initiation of the innate immune response to pathogens. Upon recognition of molecular motifs specific for microbial molecules TLR mediate pro-inflammatory cytokine secretion and enhance antigen presentation; in B cells they further promote expansion, class switch recombination and immunoglobulin secretion. As a result of their adjuvant properties, TLR ligands have become an integral component of antimicrobial vaccines. In spite of this, little is known of the direct effects of TLR engagement on B-lymphocyte function. The scope of this review is to outline the differences in TLR expression and reactivity in murine and human B-cell subsets and to provide an overview of the currently available literature. We will further discuss the possible roles of TLR in regulating B-cell effector functions and shaping antibody-mediated defence against microbial pathogens in vivo.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-11-01 |