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RESEARCH PRODUCT
The Role of Nutraceuticals in Statin Intolerant Patients.
Dimitri P. MikhailidisMichel LangloisMaria-corina SerbanRosaria Vincenza GiglioGyörgy ParaghG.b. John ManciniEric BruckertZlatko FrasBernhard PaulweberDaniel PellaMichal VrablíkPaul MuntnerOlivier S. DescampsGani BajraktariArrigo F G CiceroMarat V. EzhovŽEljko ReinerGiuseppe M.c. RosanoOlena MitchenkoAngelo Maria PattiChristos PitsavosPatrick M. MoriartyDragana NikolicManfredi RizzoNathan D. WongJacek RyszGerald F. WattsNiki KatsikiRobert S. RosensonDemosthenes B. PanagiotakosMaciej BanachStephan Von HaehlingDragan DjuricAtanas G. AtanasovAtanas G. AtanasovAmirhossein SahebkarGustavs LatkovskisDragos Vinereanusubject
Statinmedicine.drug_classDiseasecardiovascular risk ; dyslipidemia ; nutraceuticals ; position paper ; statin intolerance030204 cardiovascular system & hematologyBioinformaticsKlinikai orvostudományok03 medical and health sciences0302 clinical medicineNutraceuticalEzetimibeStatin intoleranceRed yeast riceMedicineHumansPosition paper030212 general & internal medicineEndothelial dysfunctionDyslipidemiasbusiness.industryClinical Studies as TopicOrvostudományokmedicine.diseaseCardiovascular risk3. Good healthDyslipidemiaDietary SupplementsArterial stiffnesslipids (amino acids peptides and proteins)nutraceuticalHydroxymethylglutaryl-CoA Reductase InhibitorNutraceuticalsHydroxymethylglutaryl-CoA Reductase InhibitorsCardiology and Cardiovascular MedicinebusinessDyslipidemiaposition papermedicine.drugstatin intoleranceHumandescription
Abstract Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment. These nutraceuticals could exert significant lipid-lowering activity and might present multiple non–lipid-lowering actions, including improvement of endothelial dysfunction and arterial stiffness, as well as anti-inflammatory and antioxidative properties. The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |