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RESEARCH PRODUCT
Polysaccharide-Based pH-Responsive Nanocapsules Prepared with Bio-Orthogonal Chemistry and Their Use as Responsive Delivery Systems.
Volker MailänderVolker MailänderMohammad Shafee AlkanawatiHéloïse Thérien-aubinRichard Da Costa MarquesRichard Da Costa MarquesKatharina Landfestersubject
Polymers and PlasticsBioengineeringNanotechnologyBiocompatible Materials02 engineering and technology010402 general chemistryHydrazidePolysaccharide01 natural sciencesNanocapsulesArticleBiomaterialschemistry.chemical_compoundNanocapsulesPolysaccharidesMaterials Chemistrychemistry.chemical_classificationAqueous solutionChemistrytechnology industry and agricultureHydrogen-Ion Concentration021001 nanoscience & nanotechnology0104 chemical sciencesMiniemulsionNanocarriers0210 nano-technologydescription
Bio-orthogonal reactions have become an essential tool to prepare biomaterials; for example, in the synthesis of nanocarriers, bio-orthogonal chemistry allows circumventing common obstacles related to the encapsulation of delicate payloads or the occurrence of uncontrolled side reactions, which significantly limit the range of potential payloads to encapsulate. Here, we report a new approach to prepare pH-responsive nanocarriers using dynamic bio-orthogonal chemistry. The reaction between a poly(hydrazide) crosslinker and functionalized polysaccharides was used to form a pH-responsive hydrazone network. The network formation occurred at the interface of aqueous nanodroplets in miniemulsion and led to the production of nanocapsules that were able to encapsulate payloads of different molecular weights. The resulting nanocapsules displayed low cytotoxicity and were able to release the encapsulated payload, in a controlled manner, under mildly acidic conditions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-13 | Biomacromolecules |