6533b873fe1ef96bd12d585e

RESEARCH PRODUCT

Extracranial Venous Drainage Pattern in Multiple Sclerosis and Healthy Controls: Application of the 2011 Diagnostic Criteria for Chronic Cerebrospinal Venous Insufficiency

Antongiulio GallinaPaolo CalabresiMassimiliano Di FilippoLorenzo GaetaniAlessia BianchiPaolo EusebiPaola SarchielliGabriela CardaioliMaria Di Gregorio

subject

AdultMalemedicine.medical_specialtyNeurologyChronic cerebrospinal venous insufficiencyUltrasonography Doppler TranscranialTranscranial030204 cardiovascular system & hematologyPathogenesisMultiple sclerosis03 medical and health sciences0302 clinical medicineEcho-color Doppler sonographyInternal medicineCerebral venous outflow; Chronic cerebrospinal venous insufficiency; Echo-color Doppler sonography; Multiple sclerosis; Neurology (clinical); NeurologymedicinePrevalenceHumansUltrasonographybusiness.industryMultiple sclerosisDopplerVenous drainageMiddle Agedmedicine.diseaseSurgerySettore MED/26 - NEUROLOGIADoppler sonographyChronic cerebrospinal venous insufficiencyVenous InsufficiencyNeurologyCase-Control StudiesCohortEtiologyCardiologyFemaleNeurology (clinical)Cerebral venous outflowbusiness030217 neurology & neurosurgery

description

The etiology of multiple sclerosis (MS) is still largely unknown and it has been proposed that an impaired venous drainage from the central nervous system, defined as chronic cerebrospinal venous insufficiency (CCSVI), may play a role in this. We investigated the prevalence of extracranial venous drainage pattern alterations in a cohort of MS patients based on the 2011 revised diagnostic criteria for CCSVI. Thirty-nine MS patients and 18 healthy subjects underwent blinded extra-cranial venous echo-color Doppler sonography to reveal the presence of CCSVI. There was no statistically significant difference between MS patients and healthy controls regarding CCSVI prevalence (p value = 0.53). The results challenge the hypothesis that CCSVI plays a primary role in the pathogenesis of MS.

yearjournalcountryeditionlanguage
2015-11-23
10.1159/000445540http://hdl.handle.net/11391/1385511