6533b874fe1ef96bd12d6051

RESEARCH PRODUCT

Asphyxia Activates P65 and Induces VEGF-A Gene Expression in Retina and Choroid from Newborn Piglets

Ola Didrik SaugstadV MaximoJ EscobarRønnaug SolbergAlessandro Arduini

subject

AsphyxiaPathologymedicine.medical_specialtyRetinaFetusbusiness.industryAngiogenesismedicine.disease_causeeye diseasesVascular endothelial growth factorchemistry.chemical_compoundmedicine.anatomical_structureEndocrinologychemistryInternal medicinePediatrics Perinatology and Child HealthCirculatory systemmedicinesense organsChoroidmedicine.symptombusinessOxidative stress

description

Objective: Exposure to lower oxygen causes oxidative stress and promotes angiogenesis. Asphyctic neonates have shown higher cord-blood vascular endothelial growth factor (VEGF). We hypothesized that retina and choroid having a different circulatory regulation (choroid lacks vascular auto-regulation) would acutely stimulate angiogenesis in response to short and severe hypoxemia.

yearjournalcountryeditionlanguage
2011-11-01Pediatric Research
https://doi.org/10.1038/pr.2011.352