Asphyxia Activates P65 and Induces VEGF-A Gene Expression in Retina and Choroid from Newborn Piglets

Objective: Exposure to lower oxygen causes oxidative stress and promotes angiogenesis. Asphyctic neonates have shown higher cord-blood vascular endothelial growth factor (VEGF). We hypothesized that retina and choroid having a different circulatory regulation (choroid lacks vascular auto-regulation) would acutely stimulate angiogenesis in response to short and severe hypoxemia.