6533b874fe1ef96bd12d61c1
RESEARCH PRODUCT
Estrogens and Stem Cells in Thyroid Cancer
Matilde TodaroVeronica CatalanoMaria Rosa PelizzoGiorgio StassiMariangela ZaneMariangela ZaneEmanuela ScavoMarco Bonannosubject
cancer stem cellsendocrine systemendocrine system diseasesMini ReviewEndocrinology Diabetes and MetabolismEstrogen receptorlcsh:Diseases of the endocrine glands. Clinical endocrinologyEndocrinologyCancer stem cellstem cellsgrowth factorsmedicinethyroid cancerThyroid cancerSettore MED/04 - Patologia Generalecancer stem cells (CSC)thyroid hormoneslcsh:RC648-665business.industryThyroidmedicine.diseasethyroid cancer stem cells cancer stem cells estrogens thyroid hormones growth factorsmedicine.anatomical_structureImmunologyCancer researchSignal transductionStem cellThyroid functionbusinessHormoneestrogensdescription
Recent discoveries highlight the emerging role of estrogens in the initiation and progression of different malignancies through their interaction with stem cell compartment. Estrogens play a relevant role especially for those tumors bearing a gender disparity in incidence and aggressiveness, as occurs for most thyroid diseases. Although several experimental lines suggest that estrogens promote thyroid cell proliferation and invasion, their precise contribution in stem cell compartment still remains unclear. This review underlines the interplay between hormones and thyroid function, which could help to complete the puzzle of gender discrepancy in thyroid malignancies. Defining the association between estrogen receptors’ status and signaling pathways by which estrogens exert their effects on thyroid cells is a potential tool that provides important insights in pathogenetic mechanisms of thyroid tumors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-07-01 | Frontiers in Endocrinology |