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RESEARCH PRODUCT
QT interval heterogeneities induced through local epicardial warming/cooling. An experimental study
Manuel ZarzosoLuis SuchAntonio GuillJosé MilletE RosesLuis Such-miquelAntonio CebriánÁLvaro TormosAntonio AlberolaFrancisco J. Chorrosubject
Programmed stimulationmedicine.medical_specialtyHot TemperatureArritmiaQT intervalNerve conduction velocityElectrofisiologíaTECNOLOGIA ELECTRONICAElectrocardiographyEstimulación eléctricaHeart Conduction SystemHeart RateInternal medicinemedicineAnimalsVentricular FunctionSinus rhythmVentrículo izquierdobusiness.industryArrhythmias CardiacGeneral MedicineHypothermiaLeft ventricleElectric StimulationCold TemperatureElectrophysiologyElectrophysiologyIncreased riskmedicine.anatomical_structureVentricleAnesthesiaElectrical stimulationCardiologyRabbitsmedicine.symptombusinessPericardiumArrhythmiadescription
[EN] ntroduction and objectives Abnormal QT interval durations and dispersions have been associated with increased risk of ventricular arrhythmias. The present study examines the possible arrhythmogenic effect of inducing QT interval variations through local epicardial cooling and warming. Methods In 10 isolated rabbit hearts, the temperatures of epicardial regions of the left ventricle were modified in a stepwise manner (from 22 °C to 42 °C) with simultaneous electrogram recording in these regions and in others of the same ventricle. QT and activation-recovery intervals were determined during sinus rhythm, whereas conduction velocity and ventricular arrhythmia induction were determined during programmed stimulation. Results In the area modified from baseline temperature (37 °C), the QT (standard deviation) was prolonged with maximum hypothermia (195 [47] vs 149 [12] ms; P .34). Conclusions In the experimental model employed, local variations in the epicardial temperature modulate the QT interval, activation-recovery interval, and conduction velocity. Induction of heterogeneities did not promote ventricular arrhythmia occurrence.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 |