6533b874fe1ef96bd12d6815

RESEARCH PRODUCT

The hematopoietic niche: a Drosophila model, at last.

Michèle CrozatierJoanna KrzemienAlain Vincent

subject

HemocytesCalcium-Binding ProteinsMembrane ProteinsHematopoietic Stem CellsLarvaModels Animal[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyAnimalsDrosophila ProteinsIntercellular Signaling Peptides and Proteins[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyDrosophilaSerrate-Jagged Proteins[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyBiomarkersJagged-1 ProteinTranscription Factors

description

The niche provides a specialised microenvironment necessary for maintenance of stem cells in a non differentiated state. While the hematopoietic stem cell (HSC) niche in vertebrates was the first to be recognized, Drosophila niches supporting germline stem cells were characterised first. Recent evidence for the existence of a niche maintaining hematopoietic precursors in Drosophila opens the way to study in vivo the niche/hematopoietic precursors interactions. The availability of a large collection of cell markers, mutants and sophisticated genetic tools makes Drosophila an attractive model for investigating the cellular and molecular mechanisms that are involved in these interactions.

yearjournalcountryeditionlanguage
2007-06-15Cell cycle (Georgetown, Tex.)
https://pubmed.ncbi.nlm.nih.gov/17582220