6533b881fe1ef96bd12d77ab
RESEARCH PRODUCT
Dataset relative to article "Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy"
Giuseppe LiberatoreClaudia GiannottaBlesson Punnen SajeevEmanuela MorenghiFabrizia TerenghiFrancesca GalliaPietro Emiliano DonedduFiore ManganelliDario CocitoMassimiliano FilostoGiovanni AntoniniGiuseppe CosentinoGirolama Alessandra MarfiaAngelo Maurizio ClericiGiuseppe LauriaTiziana RossoGuido CavalettiEduardo Nobile- Oraziosubject
chronic inflammatory demyelinating polyradiculoneuropathySensitivitynervous systemAnti-MAG polyneuropathyELISASpecificity.description
This record contains data related to article “Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy". Abstract For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-13 |