6533b882fe1ef96bd12db075
RESEARCH PRODUCT
Additional file 1 of Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis
Paola Di BenedettoPiero RuscittiOnorina BerardicurtiNoemi PanzeraNicolò GraziaMauro Di Vito NolfiBarbara Di FrancescoLuca NavariniAntonio MauriziNadia RucciAnna Maria TetiFrancesca ZazzeroniGiuliana GugginoFrancesco CicciaVincenza DoloEdoardo AlessePaola CiprianiRoberto Giacomellisubject
description
Additional file 1: Supplementary material 1. Mice treatments. The first day (day 0) of the procedure, 64 DBA/1 J mice were divided in 2 groups. One control group (n=32) receiving saline solution and one CIA group (n=32) receiving 100 μg of bovine type II collagen, emulsified with an equal volume of Freund’s complete adjuvant. After 18 days, the control group received saline solution and CIA mice received type II collagen and Freund’s incomplete adjuvant. At the day 19, controls and CIA mice were divided into 2 subgroups: one receiving vehicle (n=16) and one receiving 30 mg/kg/day of tofacitinib (n=16). After 35 days the first collagen administration, the mice were sacrificed and the blood collected.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |