Search results for " (ROS)"
showing 10 items of 428 documents
Efficacy and safety of ezetimibe added to atorvastatin versus atorvastatin uptitration or switching to rosuvastatin in patients with primary hypercho…
2013
Hypercholesterolemic patients (n = 1,547) at high atherosclerotic cardiovascular disease risk with low-density lipoprotein cholesterol (LDL-C) levels ≥100 and ≤160 mg/dl while treated with atorvastatin 10 mg/day entered a multicenter, randomized, double-blind, active-controlled, clinical trial using two 6-week study periods. Period I compared the efficacy/safety of (1) adding ezetimibe 10 mg (ezetimibe) to stable atorvastatin 10 mg, (2) doubling atorvastatin to 20 mg, or (3) switching to rosuvastatin 10 mg. Subjects in the latter 2 groups who persisted with elevated LDL-C levels (≥100 and ≤160 mg/dl) after period I, entered period II; subjects on atorvastatin 20 mg had ezetimibe added to th…
Comparative effects of rosiglitazone and pioglitazone on fasting and postprandial low-density lipoprotein size and subclasses in patients with Type 2…
2008
To assess the effects of pioglitazone and rosiglitazone on fasting and postprandial low-density lipoprotein (LDL) size and subclasses in patients with Type 2 diabetes.Nine Type 2 diabetic patients (age 61 +/- 10 years, body mass index 30 +/- 5 kg/m(2), glycosylated hemoglobin [HbA1c] 7.5 +/- 0.5%) were randomized in a crossover trial to rosiglitazone 4 mg b.i.d. or pioglitazone 45 mg/day for 12 weeks with an 8-week wash-out period. LDL size and subclasses were determined by non-denaturing polyacrylamide gradient gel electrophoresis. A standardized breakfast was served and variables were assessed after 3 and 6 h.HbA1c, insulin sensitivity (as assessed by the homeostasis model assessment) and…
Le modifiche agli articoli 61, 572 e 612-bis del codice penale, nonché al codice delle leggi antimafia e delle misure di prevenzione (art. 9, l. 19 l…
2020
Il contributo si sofferma sulle modifiche agli artt. 61, 572 e 612-bis del codice penale, nonché al codice delle leggi antimafia e delle misure di prevenzione, dovute all'art. 9 della l. 19 luglio 2019, n. 69.
Phytosociological analysis of the Genista sp. pl. garrigues of the Cisto-Lavanduletea and Rosmarinetea officinalis classes in the South-Tyrrhenian ar…
2015
The study reviews the Genista sp. pl. garrigues ascribable to the classes Cisto-Lavanduletea (acidophilous communities on volcanics and quartzarenites) and Rosmarinetea officinalis (basiphilous communities on calcareous and calcareous-dolomite substrates), in the southern territories of the Italo-Tyrrhenian Province. The floristic-synecological characterization of the identified coenoses led to the description and/or redefinition of various new syntaxa. They are distributed in the two new suballiances Calicotomo villosae–Genistenion tyrrhenae and Genisto aristatae–Calicotomenion infestae of the class Cisto- Lavanduletea (Lavanduletalia stoechadis and Calicotomo villosae–Genistion tyrrhenae)…
Oppositori a Messina nel Trecento. Il caso di Enrico Rosso
2021
Il saggio mette a fuoco il caso di Enrico Rosso, conte di Aidone, protagonista della vita politica messinese negli anni centrali del XIV secolo. Uomo dal temperamento inquieto, ambiguo e calcolatore, Rosso si ritrovò a oscillare tra latini e catalani, denominazioni che implicano, ha evidenziato la storiografia più recente, non appartenenze nazionali ma l’aggregarsi di schieramenti in competizione per il potere locale, tra fedeltà e ribellione al re. Sul suo agire pesò anche l'esclusione dal vicariato collettivo che vide l'affermazione, a partire del 1377, di quattro grandi famiglie che approfittarono della fragilità del potere regio per esercitare sull’isola la loro influenza. The paper wil…
Lack of Functional Trehalase Activity in Candida parapsilosis Increases Susceptibility to Itraconazole
2022
Central metabolic pathways may play a major role in the virulence of pathogenic fungi. Here, we have investigated the susceptibility of a Candida parapsilosis mutant deficient in trehalase activity (atc1Δ/ntc1Δ strain) to the azolic compounds Fluconazole and Itraconazole. A time-course exposure to Itraconazole but not Fluconazole induced a significant degree of cell-killing in mutant cells compared to the parental strain. Flow cytometry determinations indicated that Itraconazole was able to induce a marked production of endogenous ROS together with a simultaneous increase in membrane potential, these effects being irrelevant after Fluconazole addition. Furthermore, only …
Microrganismi fungini associati al punteruolo rosso delle palme in Sicilia
2009
Il servizio della Croce Rossa Italiana nelle zolfare di Sicilia dal 1898 al 1913.
2008
La Croce Rossa Italiana nelle miniere di zolfo in Sicilia ha iniziato a svolgere il suo primo servizio in tempo di pace nel 1898, a 34 anni dalla sua fondazione. E' stata ammirevole l'attività di I. Di Giovanni e di altri medici, anche dell'Università degli Studi di Palermo, quali A. Trmbusti ed i suoi allievi A. Amato e G. Gabrielli. Il servizio ha interessato all'esordio gli infortuni sul lavoro e successivamente anche la lotta all'anchilostomiasi e alla malari. Le norme hanno imposto agli industriali lo sviluppo di un sistema di tutela assicurativa e la costituzione in sindacato, al pari di altre nazioni europee. la presenza della Croce Rossa si è protratta fino al 1913, quando il Sindac…
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
2010
This review highlights the important role of redox signaling between mitochondria and NADPH oxidases. Besides the definition and general importance of redox signaling, the cross-talk between mitochondrial and Nox-derived reactive oxygen species (ROS) is discussed on the basis of 4 different examples. In the first model, angiotensin-II is discussed as a trigger for NADPH oxidase activation with subsequent ROS-dependent opening of mitochondrial ATP-sensitive potassium channels leading to depolarization of mitochondrial membrane potential followed by mitochondrial ROS formation and respiratory dysfunction. This concept was supported by observations that ethidium bromide-induced mitochondrial d…
Oxidant antioxidants and adaptive responses to exercise.
2015
The extensive damage produced by unaccustomed (acute) exercise and the health benefits of regular physical activity are well-known phenomena as well as the role played in them by reactive oxygen species (ROS). The present issue reports some interesting studies showing that the Janus faced effects of exercise-induced ROS in skeletal muscle. Most studies dealing with ROS contribution to acute exercise-induced tissue damage determine the levels of markers of oxidative damage to specific substances but they do not take into account total redox status of an individual before and after exercise. In their research article D. Stagos et al. used markers measuring plasma static (sORP) and capacity (c…