Search results for " 11"
showing 10 items of 591 documents
Identification and expression of the 11β‐steroid hydroxylase from Cochliobolus lunatus in Corynebacterium glutamicum
2019
Hydroxylation of steroids has acquired special relevance for the pharmaceutical industries. Particularly, the 11β-hydroxylation of steroids is a reaction of biotechnological importance currently carried out at industrial scale by the fungus Cochliobolus lunatus. In this work, we have identified the genes encoding the cytochrome CYP103168 and the reductase CPR64795 of C. lunatus responsible for the 11β-hydroxylase activity in this fungus, which is the key step for the preparative synthesis of cortisol in industry. A recombinant Corynebacterium glutamicum strain harbouring a plasmid expressing both genes forming a synthetic bacterial operon was able to 11β-hydroxylate several steroids as subs…
SQL datubāžu optimizācijas iespējas un salīdzinājums
2015
Datubāzes veiktspēja ir ļoti atkarīga no optimizatora darbības, zināmiem datubāzes defektiem un neprecīzas statistikas. Saturīgas statistikas palīdz strādāt un izvēlēties ātrākos SQL pieprasījumu izpildes plānus. Lai optimizators spētu atbilstoši darboties, tam ir nepieciešamas kvalitatīvas statistikas, bet bieži vien to vākšanas process ir laikietilpīgs un resursus patērējošs. Šajā darbā tiek apskatīti un salīdzināti populārāko datubāžu optimizatoru darbības principi un uzbūve, statistiku vākšanas uzstādījumi un parametri gan teorētiski, gan praktiski. Bakalaura darbs uzskatāms par informatīvu materiālu ar mērķi apkopot informāciju par datubāzēm un optimizācijas iespējām.
Training During the COVID-19 Lockdown: Knowledge, Beliefs, and Practices of 12,526 Athletes from 142 Countries and Six Continents
2021
Abstract Objective Our objective was to explore the training-related knowledge, beliefs, and practices of athletes and the influence of lockdowns in response to the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods Athletes (n = 12,526, comprising 13% world class, 21% international, 36% national, 24% state, and 6% recreational) completed an online survey that was available from 17 May to 5 July 2020 and explored their training behaviors (training knowledge, beliefs/attitudes, and practices), including specific questions on their training intensity, frequency, and session duration before and during lockdown (March–Jun…
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes
2015
Item does not contain fulltext Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining a global resource. We identify 112 candidate ciliogenesis and ciliopathy genes, including 44 components of the ubiquitin-proteasome system, 12 G-protein-coupled receptors, and 3 pre-mRNA processing factors (PRPF6, PRPF8 and PRPF31) mutated in autosomal dominant retinitis pigmentosa. The PRPFs localize to the connecting cilium, and PRPF8- and PRPF31-mutated cells have ciliary defects. Combining the screen with exome sequen…
Common variants conferring risk of schizophrenia
2009
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative ris…
Observation of Time-Reversal Violation in the B0 Meson System
2012
Although CP violation in the B meson system has been well established by the B factories, there has been no direct observation of time reversal violation. The decays of entangled neutral B mesons into definite flavor states ($B^0$ or $\bar{B}^0$), and $J/\psi K_S^0$ or $c\bar{c} K_S^0$ final states (referred to as $B_+$ or $B_-$), allow comparisons between the probabilities of four pairs of T-conjugated transitions, for example, $\bar{B}^0 \rightarrow B_-$ and $B_- \rightarrow \bar{B}^0$, as a function of the time difference between the two B decays. Using 468 million $B\bar{B}$ pairs produced in $\Upsilon(4S)$ decays collected by the BABAR detector at SLAC, we measure T-violating parameter…
Search for charged lepton flavor violation in narrow Y decays
2010
Charged-lepton flavor-violating processes are unobservable in the standard model, but they are predicted to be enhanced in several extensions to the standard model, including supersymmetry and models with leptoquarks or compositeness. We present a search for such processes in a sample of 99 × 10 6 Υ ( 2 S ) decays and 117 × 10 6 Υ ( 3 S ) decays collected with the BABAR detector. We place upper limits on the branching fractions B ( Υ ( n S ) → e ± τ ∓ ) and B ( Υ ( n S ) → μ ± τ ∓ ) ( n = 2 , 3 ) at the 10 − 6 level and use these results to place lower limits of order 1 TeV on the mass scale of charged-lepton flavor-violating effective operators.
Search for large extra spatial dimensions in dimuon production with the D0 detector
2005
We present the results of a search for the effects of large extra spatial dimensions in $p{\bar p}$ collisions at $\sqrt{s} =$ 1.96 TeV in events containing a pair of energetic muons. The data correspond to 246 \ipb of integrated luminosity collected by the \D0 experiment at the Fermilab Tevatron Collider. Good agreement with the expected background was found, yielding no evidence for large extra dimensions. We set 95% C.L. lower limits on the fundamental Planck scale between 0.85 TeV and 1.27 TeV within several formalisms. These are the most stringent limits achieved in the dimuon channel to date.
La vida de Sant Pedro Gonçalez Telmo abogado de los nauegantes
1587
Sign.: [paràgraf]8, *8, A-Z8, Aa-Ff8, Gg10 Grav. xil. de Sant Domènec signat "S.D.", anagrama IHS en port. v. - Caplletres. - P. 156 repetida
Scriptum super IV libros Sententiarum. Liber 3
Ms Títol donat pel catalogador Col·lació: Vitel·la, f. iii (paper) + 182 + iii (paper) ; numeració moderna a llapis ; reclams horitzontals cada dotze fulls, alguns tallats; signatures de quadern Composició: Escrit a dues columnes a 48 línies (f. 1rb). Pautat amb mina de plom Escriptura: Gòtica textual cal·ligràfica. Anotacions marginals contemporànies i posteriors Decoració: Caplletra inicial decorada amb tinta de color blau i vermell. Caplletres menors, calderons i titolets amb les mateixos colors Enquadernació: Plateresc-mudèjar original, pell marró sobre fusta, amb ferros freds. A la coberta anterior, amb ferros daurats el títol: "Scriptum.Sup[er] III.S[ententiarum]" i escut d'armes del …