Search results for " 14"
showing 10 items of 676 documents
El mejor pastor descalzo, san Pascual Baylón o la incursión teatral de Ginés Campillo de Bayle
2016
Resumen: Cuando los ultimos decenios del siglo XVII iban marcando el final de la Casa de Austria en Espana, un clerigo nacido en Elche (Alicante), Gines Campillo de Bayle, intento su incursion en el mundo literario de la epoca. Su figura y obra, por un motivo u otro, siempre han estado rodeadas por un entorno de misterio, desgraciada fortuna y escasa estimacion. Valorado con precaucion por unos pocos, ignorado o criticado por la mayoria, gran parte de su produccion lirica, narrativa y teatral ha conseguido llegar, a pesar de todo, a nuestras manos. Un ejemplo de lo senalado es la comedia teatral, asi titulada por el propio autor, El mejor pastor descalzo, san Pascual Baylon ; toda una demos…
Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tum…
2021
Simple Summary Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the target of interest, site-specific conjugation of these functional groups is preferred. Here, we optimized site-specific conjugation of both a chelator for binding of a radiometal and a photosensitizer to epidermal growth factor receptor (EGFR) binding VHH 7D12. We characterized this dual-labeled VHH for nuclear imaging and targeted photodynamic therapy of EGFR-expressing tumors. Abstract Variable domains of heavy chain only antibodies (VHHs) are valu…
Expression of Hugl-1 is strongly reduced in malignant melanoma.
2005
The human gene Hugl-1 (Llgl/Lgl1) has significant homology to the Drosophila tumor suppressor gene lethal(2)giant larvae (lgl). The lgl gene codes for a cortical cytoskeleton protein, Lgl, that is involved in maintaining cell polarity and epithelial integrity. We speculate that Hugl-1 might play a role in epithelial-mesenchymal transition (EMT) and that loss of Hugl-1 expression plays a role in the development or progression of malignant melanoma. Thus, we evaluated melanoma cell lines and tissue samples of malignant melanoma for loss of Hugl-1 transcription. We found that Hugl-1 was downregulated or lost in all cell lines and in most of the tumor samples analysed, and that these losses wer…
EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum.
2014
Contains fulltext : 137861.pdf (Publisher’s version ) (Closed access) BACKGROUND: Care for patients with colon and rectal cancer has improved in the last 20years; however considerable variation still exists in cancer management and outcome between European countries. Large variation is also apparent between national guidelines and patterns of cancer care in Europe. Therefore, EURECCA, which is the acronym of European Registration of Cancer Care, is aiming at defining core treatment strategies and developing a European audit structure in order to improve the quality of care for all patients with colon and rectal cancer. In December 2012, the first multidisciplinary consensus conference about…
Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids
2021
AbstractThe prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination, which are sustained by the cancer stem cell (CSC) population. The main driver of the CSC gene expression program is Wnt signaling, and previous reports indicate that Wnt3a can activate p38 MAPK. Besides, p38 was shown to feed into the canonical Wnt/β-catenin pathway. Here we show that patient-derived locally advanced CRC stem cells (CRC-SCs) are characterized by increased expression of p38α and are “addicted” to its kinase activity. Of note, we found that stage III CRC patients with high p38α levels display…
Second St. Gallen European Organisation for Research and Treatment of Cancer Gastrointestinal Cancer Conference: consensus recommendations on controv…
2016
Contains fulltext : 171468pub.pdf (Publisher’s version ) (Open Access) Primary treatment of rectal cancer was the focus of the second St. Gallen European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Cancer Conference. In the context of the conference, a multidisciplinary international expert panel discussed and voted on controversial issues which could not be easily answered using published evidence. Main topics included optimal pretherapeutic imaging, indication and type of neoadjuvant treatment, and the treatment strategies in advanced tumours. Here we report the key recommendations and summarise the related evidence. The treatment strategy for localised rect…
Cappelle di palazzo nella Sicilia del Trecento
2018
Nei palazzi e nei castelli dell’aristocrazia siciliana, realizzati ex-novo o rinnovati nel corso del XIV secolo, la presenza di cappelle palatine appare una costante. Inserite tra gli ambienti della stessa residenza o costruite in volumi autonomi ma adiacenti alla prima, esse contribuiscono a definirne il rango, in un ambiguo equilibrio tra sfera pubblica e privata. Infatti, sebbene destinate essenzialmente a una fruizione privata - della quale tuttavia non si conoscono con precisione modalità e frequenza - si tratta al contempo degli ambienti definiti con maggiore cura e con scelte formali che appaiono mirate a perseguire precise strategie di autorappresentazione, che oscillano tra modelli…
Propositio facta per oratores Innocentii VIII coram Carolo VIII, Francorum rege
1488
Sign.: a6. - Data completa, d. 20 gener, 1488 L. gòt. - 33 lín. - Capll. grav
Teresa y Luis, Luis y Teresa. Dos santos en tiempos recios
2016
Resumen: El presente articulo analiza la relacion entre dos grandes santos espanoles de la Contrarreforma Catolica, Teresa de Jesus y el dominico fray Luis Bertran Palabras clave: Teresa de Jesus, Luis Bertran, Santos, Contrarreforma, Carmelitas Descalzos, Dominicos, Siglo XVI Abstract: The present article analyses the relation between two big Spanish saints of the Catholic Counter-reformation, Teresa de Jesus and the Dominican monk Luis Bertran Keywords : Teresa de Jesus, Luis Bertran, Saints, Counter-reformation, Discalced Carmelite, Dominicans, 16th century
Los ballesteros del rey, los arneses empeñados y otros nuevos documentos sobre Pero Niño
2018
RESUMENSe presentan cuatro documentos hasta ahora desconocidos sobre Pero Niño, datados entre 1404 y 1431, que arrojan luz sobre algunos episodios poco detallados o silenciados en El Victorial, la biografía caballeresca que le dedicó Gutierre Díaz de Games.PALABRAS CLAVEPero Niño, Gutierre Díaz de Games, El Victorial.ABSTRACTThis study presents four unknown documents about Pero Niño, dated between 1404 and 1431. They shed light on several episodes that are undetailed or silenced in El Victorial, the chivalric biography written by Gutierre Díaz de Games.KEYWORDSPero Niño, Gutierre Díaz de Games, El Victorial.