Search results for " 16"

C3 Drives Inflammatory Skin Carcinogenesis Independently of C5

2021

Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (cSCC) is the most common form of cancer and can occur as a consequence of DNA damage to the epithelium by UVR or chemical carcinogens. There is growing evidence that the complement system is involved in cancer immune surveillance; however, its role in cSCC remains unclear. Here, we show that complement genes are expressed in tissue from patients with cSCC, and C3 activation fragments are present in cSCC biopsies, indicating complement activation. Using a range of complement-deficient mice in a two-stage mouse model of chemically-induced cSCC, where a subclinical dose of 7,12-dimethylbenz[a]anthracene causes oncogenic mutatio…

Functional comparison of bacteria from the human gut and closely related non-gut bacteria reveals the importance of conjugation and a paucity of moti…

2016

International audience; The human GI tract is a complex and still poorly understood environment, inhabited by one of the densest microbial communities on earth. The gut microbiota is shaped by millennia of evolution to co-exist with the host in commensal or symbiotic relationships. Members of the gut microbiota perform specific molecular functions important in the human gut environment. This can be illustrated by the presence of a highly expanded repertoire of proteins involved in carbohydrate metabolism, in phase with the large diversity of polysaccharides originating from the diet or from the host itself that can be encountered in this environment. In order to identify other bacterial fun…

Draft genomes of Nautella italica strains CECT 7645(T) and CECT 7321: Two roseobacters with potential pathogenic and biotechnological traits.

2015

Nautella italica is a member of the family Rhodobacteraceae described in 2009. Strain LMG 24365(T) (=CECT 7645(T), =DSM 26436(T), =CCUG 55857(T)) was isolated from a marine electroactive biofilm growing in a stainless steel cathode exposed to natural water in Genoa, Italy. Strain AD 41 (=CECT 7321) was isolated from water surrounding cultivated gilthead seabream larvae in Cadiz, Spain. The genomes of strains CECT 7645(T) and CECT 7321 were sequenced, assembled, annotated and compared. Here we describe the most relevant findings: biofilm formation, quorum sensing, resistance to multiple drugs, heavy metals and oxidative stress, cytotoxins, and poly-β-hydroxybutyrate (PHB) production genes. T…

Methylophaga and Hyphomicrobium can be used as target genera in monitoring saline water methanol-utilizing denitrification.

2016

Abstract Which bacterial taxonomic groups can be used in monitoring saline water methanol-utilizing denitrification and whether nitrate is transformed into N2 in the process are unclear. Therefore, methylotrophic bacterial communities of two efficiently functioning (nitrate/nitrite reduction was 63–96 %) tropical and cool seawater reactors at a public aquarium were investigated with clone library analysis and 454 pyrosequencing of the 16S rRNA genes. Transformation of nitrate into N2 was confirmed using 15N labeling in incubation of carrier material from the tropical reactor. Combining the data with previous study results, Methylophaga and Hyphomicrobium were determined to be suitable targe…

HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory

2019

ABSTRACT HPV16 infections are associated with a variety of cancers and there is compelling evidence that the transforming activity of HPV16 critically depends on the expression of the viral oncoproteins E6 and E7. Therapeutic cancer vaccines capable of generating durable and specific immunity against these HPV16 antigens hold great promise to achieve long-term disease control. Here we show in mice that HPV16 E7 RNA-LPX, an intravenously administered cancer vaccine based on immuno-pharmacologically optimized antigen-encoding mRNA, efficiently primes and expands antigen-specific effector and memory CD8+ T cells. HPV-positive TC-1 and C3 tumors of immunized mice are heavily infiltrated with ac…

The cholinergic system in Down's syndrome

2006

The cholinergic system is one of the most important modulatory neurotransmitter systems in the brain. Alterations of the transmission communicators are accompanied by reduction of the cortical activity, which is associated with a learning and memory deficit. Down's syndrome is a pathological condition characterized by a high number of abnormalities that involve the brain.The cholinergic system is involved in alterations of the neurological system such as severe learning difficulties.To explain these alterations, important results are obtained from studies about murine trisomy 16 (animal model of Down's syndrome).The results obtained provide useful elements in the improvement of knowledge ab…

The Value Relevance of Operating Lease Liabilities: Economic Effects of IFRS 16

2018

The new IASB and FASB models for leases aim to improve the quality of financial reporting. To this end, both standard setters impose the recognition of assets and liabilities for operating leases. Meanwhile, preparers have been strongly lobbying against these changes, as in their view the new treatment will lead to negative economic consequences. We undertake a value‐relevance study to examine whether as‐if capitalised operating leases are priced by market users in a relatively unexplored setting. We consider Spanish listed firms, and employ hand‐collected data on operating leases disclosed in the notes to the financial statements to constructively capitalise the assets and liabilities. Our…

Influence of the drawing process on the defect generation in multistep-index germanium-doped optical fibers

2009

International audience; Variation of germanium lone pair center (GLPC) concentration in germanosilicate multistep-index optical fibers and preforms was studied using confocal microscopy luminescence technique. The experimental results provide evidence that in the central core region ([Ge] ~11 wt. % ) of our specific canonical samples the ratio [GLPC]/[Ge] is five times larger in fiber than in preforms. The relative influence of the glass composition and of the drawing process on the generation efficiency of the GLPC defects that drive the glass photosensitivity is discussed. The radial distribution of these defects suggests a possible enhancement of the defect creation related to the intern…

Diversità dei procarioti in acque di falda contaminate da solventi clorurati

2021

Lielvaru cīņa par ietekmi Livonijā Dionīsija Fabrīcija “Livonijas vēstures” atspoguļojumā

2019

Bakalaura darbs “Lielvaru cīņa par ietekmi Livonijā Dionīsija Fabrīcija “Livonijas vēstures” atspoguļojumā” pēta 17.gs. sākuma vēstures avotu, pievēršas Dionīsija Fabrīcija piedāvātajām Baltijas jūras reģiona lielvaru – Polijas – Lietuvas, Zviedrijas, Krievijas, Dānijas – interešu un darbību attēlojumam. Bakalaura darba mērķis ir konstatēt Dionīsija Fabrīcija attieksmi pret dažādām Livonijas politikā iesaistītajām lielvarām un izvērtēt viņa piedāvāto vēstures norišu skaidrojumu. Rezultātā noskaidrots, ka Fabrīcija attieksmē pret lielvarām ieceļas Polija kā taisnīguma aizstāve, kas Livonijā cīnās par miera nodrošināšanu. Tai pretstatā pārējās varas, īpaši, Zviedrija, tiek tēlotas kā miera ja…