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RESEARCH PRODUCT
The cholinergic system in Down's syndrome
V. CaminitiVincenzo FodaleFederica MafricaGiovanni Grassosubject
030506 rehabilitationDown syndromeCentral nervous systemTrisomyDiseaseSynaptic TransmissionHealth Professions (miscellaneous)Mice03 medical and health sciencesMemorymedicineAnimalsHumansLearningAttentionReceptors Cholinergic0501 psychology and cognitive sciencesDown's syndromePathologicalCerebral CortexHealth PolicyMedicine (all)05 social sciencesCognitive disorderCholinergic systemBrainTrisomy 16medicine.diseaseChromosomes MammalianDevelopmental disorderDisease Models AnimalPsychiatry and Mental healthmedicine.anatomical_structureCholinergic FibersAnimals Attention; physiology Brain; physiopathology Cerebral Cortex; physiopathology Cholinergic Fibers; physiology Chromosomes; Mammalian Disease Models; Animal Down Syndrome; genetics/physiopathology Humans Learning; physiology Memory; physiology Mice Receptors; Cholinergic; physiology Synaptic Transmission; physiology TrisomyIntellectual disabilitieDown Syndrome0305 other medical sciencePsychologyTrisomyNeuroscience050104 developmental & child psychologydescription
The cholinergic system is one of the most important modulatory neurotransmitter systems in the brain. Alterations of the transmission communicators are accompanied by reduction of the cortical activity, which is associated with a learning and memory deficit. Down's syndrome is a pathological condition characterized by a high number of abnormalities that involve the brain.The cholinergic system is involved in alterations of the neurological system such as severe learning difficulties.To explain these alterations, important results are obtained from studies about murine trisomy 16 (animal model of Down's syndrome).The results obtained provide useful elements in the improvement of knowledge about the neurological and neurotransmissional alterations that are responsible for the neurobiological characteristics of Down's syndrome.These data potentially justify, in these patients, the therapeutic use of drugs that are principally administered to improve the severe learning difficulties of people with Alzheimer's disease, and suggest a trend which generates a hypothesis worthy of further exploration. © 2006 Sage Publications.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-01-01 | Journal of Intellectual Disabilities |