Search results for "Down"

Integrated analytical methodologies for the study of corrosion processes in archaeological bronzes

2011

Abstract The investigations on structure and micro-chemical composition of archaeological metal alloys are needed in archaeometry. The aim of this study is devoted both to acquire information about their provenance and production technology, and to improve our understanding about the corrosion processes. In this paper we present the study of the corrosion phenomena of bronze samples, laboratory-made according to binary, ternary and quaternary alloys typical of Roman archaeometallurgical production through an integrated methodology based on the use of non or micro invasive physical techniques. Among the analysed samples, two were artificially aged through burial in the archaeological site of…

Impact of antigen presentation on TCR modulation and cytokine release: implications for detection and sorting of antigen-specific CD8+ T cells using …

2002

Abstract Soluble MHC class I molecules loaded with antigenic peptides are available either to detect and to enumerate or, alternatively, to sort and expand MHC class I-restricted and peptide-reactive T cells. A defined number of MHC class I/peptide complexes can now be implemented to measure T cell responses induced upon Ag-specific stimulation, including CD3/CD8/ζ-chain down-regulation, pattern, and quantity of cytokine secretion. As a paradigm, we analyzed the reactivity of a Melan-A/MART-1-specific and HLA-A2-restricted CD8+ T cell clone to either soluble or solid-phase presented peptides, including the naturally processed and presented Melan-A/MART-1 peptide AAGIGILTV or the peptide ana…

Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain

2009

Recently, we could demonstrate in rats that a short transient oligemic period of only 20-minute duration, induced by systemic hypotension, resulted in a transient decline of spatial memory capacities without any histological damage over a subsequent period of 6 months. In our present study, we checked for more subtle alterations within the highly vulnerable hippocampal CA1 subfield using quantification of neuronal cell density and semi-quantitative analysis of the ischemia-sensitive protein MAP2. Since hippocampal excitatory and inhibitory neurotransmitter receptors are crucially involved in spatial memory processes, quantitative in vitro receptor autoradiography was performed using [(3)H]M…

IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose rece…

1998

SUMMARYOur study demonstrates that antigen-presenting liver sinusoidal endothelial cells (LSEC) induce production of interferon-gamma (IFN-γ) from cloned Th1 CD4+ T cells. We show that LSEC used the mannose receptor for antigen uptake, which further strengthened the role of LSEC as antigen-presenting cell (APC) population in the liver. The ability of LSEC to activate cloned CD4+ T cells antigen-specifically was down-regulated by exogenous prostaglandin E2 (PGE2) and by IL-10. We identify two separate mechanisms by which IL-10 down-regulated T cell activation through LSEC. IL-10 decreased the constitutive surface expression of MHC class II as well as of the accessory molecules CD80 and CD86 …

Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.

2016

Pre-eclampsia (PE), which affects ∼8% of first pregnancies, is associated with faulty placentation. Extravillous cytotrophoblasts (CTBs) fail to differentiate properly, contributing to shallow uterine invasion and deficient spiral artery remodeling. We studied the effects of severe PE (sPE) on the smooth chorion portion of the fetal membranes. The results showed a significant expansion of the CTB layer. The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally upregulate as they exit the placenta. Transcriptomics revealed the dysregulated expression of many genes (e.g. placental proteins, markers of oxidative stress). We confirmed an sPE-related incr…

Study of postural control and body balance in subjects with Down syndrome

2020

Purpose. Body imbalance and poor postural control have negative impact on gait and may increase the risk of falling in healthy individuals as well as those with Down syndrome (DS). Since people with DS have lower physical levels than people who do not present this condition, the purpose of our research was to compare features of postural control and body balance between subjects affected by DS and a control sample. Methods. Participants enrolled were divided into the following two groups: A DS group (DSG; n = 22; 9 females and 13 males; age range: 16-36 years) and an age-matched control group (CG; n = 25; 11 females and 14 males; age range: 16-36 years). All participants were subjected to t…

Tecniche e Modelli di Cartografia Digitale Predittiva dei Suoli Basati sull'Approccio SCORPAN per il Downscaling della Nuova Carta dei Suoli della Si…

2013

Response of seagrasses and marine biofilms to natural acidification at CO2 vents

Nel corso degli ultimi 200 anni, circa il 30% delle emissioni antropogeniche di CO2 nell’atmosfera sono state assorbite dagli oceani, provocando un abbassamento medio dei livelli di pH oceanici pari a circa 0.1 unità. Questo fenomeno, noto come acidificazione degli oceani, sta determinando conseguenze negative sugli ecosistemi marini e sul loro funzionamento. Le attuali proiezioni climatiche suggeriscono che, in futuro, i cambiamenti climatici continueranno e si intensificheranno se non verranno adottate efficaci misure di mitigazione. Riuscire a valutare la risposta degli ecosistemi marini ai cambiamenti climatici costituisce una vera sfida per la ricerca scientifica, non solo per la diffi…

Periodontal disease associated to systemic genetic disorders

2007

A number of systemic disorders increase patient susceptibility to periodontal disease, which moreover evolves more rapidly and more aggressively. The underlying factors are mainly related to alterations in immune, endocrine and connective tissue status. These alterations are associated with different pathologies and syndromes that generate periodontal disease either as a primary manifestation or by aggravating a pre-existing condition attributable to local factors. This is where the role of bacterial plaque is subject to debate. In the presence of qualitative or quantitative cellular immune alterations, periodontal disease may manifest early on a severe localized or generalized basis - in s…

Laser-induced plasma spectroscopy in near vacuum ultraviolet using ordinary spectrograph and ICCD

2002

An experimental setup to measure laser-induced plasma emission spectra with an ordinary Czerny-Turner spectrograph and intensified charge-coupled device in the near vacuum ultraviolet down to 130 nm is described. Spectra of bromine, chlorine and iodine were recorded to demonstrate the performance of the setup.