Search results for " ACTIVATION"
showing 10 items of 1535 documents
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.
2005
Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …
Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation
2009
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …
Dihydrogen Activation by Antiaromatic Pentaarylboroles
2010
Facile metal-free splitting of molecular hydrogen (H2) is crucial for the utilization of H2 without the need for toxic transition-metal-based catalysts. Frustrated Lewis pairs (FLPs) are a new class of hydrogen activators wherein interactions with both a Lewis acid and a Lewis base heterolytically disrupt the hydrogen−hydrogen bond. Here we describe the activation of hydrogen exclusively by a boron-based Lewis acid, perfluoropentaphenylborole. This antiaromatic compound reacts extremely rapidly with H2 in both solution and the solid state to yield boracyclopent-3-ene products resulting from addition of hydrogen atoms to the carbons α to boron in the starting borole. The disruption of antiar…
Application of the Chinese Version of the BIS/BAS Scales in Participants With a Substance Use Disorder: An Analysis of Psychometric Properties and Co…
2020
Carver and White developed the Behavioral Inhibition/Behavioral Activation Scales (the BIS/BAS Scales) based on Reinforcement Sensitivity Theory proposed by Gray. Subsequent studies proposed that substance abuse was closely related to Behavioral Inhibition System (BIS) and Behavioral Activation System (BAS). However, researches on the psychometric properties of the BIS/BAS scales in clinical samples are scarce. The present study was conducted to analyze the applicability of the BIS/BAS scales in a sample suffering from a substance use disorder (SUD) and undergoing treatment in compulsory detoxification institutions (n = 1117). Meanwhile, 822 community residents were selected for comparison.…
Inverse estimation of the cardiac purkinje system from electroanatomical maps
2020
Las enfermedades cardiovasculares son la primera causa de mortalidad en el mundo, con 17.7 millones de muertes cada año, aproximadamente el 31% de las muertes en todo el mundo (Organización Mundial de la Salud (OMS) 2018). Las arritmias ventriculares son una causa importante de muerte súbita, que representa aproximadamente la mitad de la mortalidad cardíaca. Algunas de esas arritmias se atribuyen a la red de Purkinje (PKN), que bajo ciertas condiciones puede generar ritmos focales automáticos, y su configuración de red puede sostener circuitos eléctricos reentrantes. Los ritmos focales originados desde la red de Purkinje pueden servir como puntos de inicio en casos de fibrilación ventricula…
Comparison of the Properties of Activated Carbons Produced in One-Stage and Two-Stage Processes
2018
Activated carbons (ACs) can be produced from biomass in a thermal process either in a direct carbonization-activation process or by first carbonizing the biomass and later activating the bio-chars into activated carbons. The properties of the ACs are dependent on the type of process used for production. In this study, the properties of activated carbons produced in one-stage and two-stage processes are considered. Activated carbons were produced by physical activation of two types of starting materials: bio chars produced from spruce and birch chips in a commercial carbonization plant and from the corresponding raw chips. The activated carbons produced were characterized regarding specific …
The acute effects of different high-intensity conditioning activities on sprint performance differ between sprinters of different strength and power …
2021
The purpose of the present study was to examine the effect of different conditioning activities (CAs) on short-term increase in sprint performance. In twelve male sprinters (21.1+2.6 years, 100 m performance: 11.5+0.6 s) their body composition, half squat maximum strength, 100 m sprinting and countermovement jump performances were evaluated. The performance of a 50 m sprint (splits at 10 m, 30 m and 50 m) was evaluated before and 5, 10 and 15 min after four postactivation performance enhancement CAs on different occasions: [1] 3 sets x 4 s maximum isometric half squat (IHF), [2] 3 sets x 3 consecutive countermovement jumps (cCMJs), [3] 3 repetitions x 30 m overspeed sprinting (OVSP) and [4]…
Estar al otro lado de la mesa. Profesionales de los servicios públicos de empleo ante los dilemas de la activación laboral
2019
Under the paradigm of activation, the Public Employment Services has been reshaped by two levels of contractualization. On one hand, the collaboration of the administration with a network of agents on the programme scheme that make up the active policies of employment. On the other hand, the unemployed person?s access to a compartmentalized offer of services and individually taking responsibility for finding work. This double contractualization reveals redefinition of lowering public responsibility faced with the problem of unemployment that this activation supposes. This paper analyses how this redesign has an impact on how professionals serve the unemployed population. This lays bare, in …
Enhancing Metastability by Dissipation and Driving in an Asymmetric Bistable Quantum System.
2018
The stabilizing effect of quantum fluctuations on the escape process and the relaxation dynamics from a quantum metastable state are investigated. Specifically, the quantum dynamics of a multilevel bistable system coupled to a bosonic Ohmic thermal bath in strong dissipation regime is analyzed. The study is performed by a non-perturbative method based on the real-time path integral approach of the Feynman-Vernon influence functional. We consider a strongly asymmetric double well potential with and without a monochromatic external driving, and with an out-of-equilibrium initial condition. In the absence of driving we observe a nonmonotonic behavior of the escape time from the metastable regi…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…