Search results for " ACh"
showing 10 items of 432 documents
The Molecular Anatomy of Human Hsp60 and its Similarity with that of Bacterial Orthologs and Acetylcholine Receptor Reveal a Potential Pathogenetic R…
2012
Heat-shock protein 60 (Hsp60) is ubiquitous and highly conserved being present in eukaryotes and prokaryotes, including pathogens. This chaperonin, although typically a mitochondrial protein, can also be found in other intracellular sites, extracellularly, and in circulation. Thus, it can signal the immune system and participate in the development of inflammation and immune reactions. Both phenomena can be elicited by human and foreign Hsp60 (e.g., bacterial GroEL), when released into the blood by infectious agents. Consequently, all these Hsp60 proteins become part of a complex autoimmune response characterized by multiple cross reactions because of their structural similarities. In this s…
ESE. Estudios sobre educación
2018
El objetivo es analizar la influencia del compromiso académico sobre la satisfacción de los estudiantes universitarios con su facultad, a partir del apoyo a la autonomía por el profesorado. Se administran escalas de Apoyo a la Autonomía, Compromiso Académico y Satisfacción con la Facultad, a 870 estudiantes universitarios dominicanos (50.6% hombres, 49.4% mujeres). Se aplican Análisis Factoriales Confirmatorios y Modelos de Ecuaciones Estructurales. Los resultados reflejan la influencia del apoyo a la autonomía por los profesores sobre la satisfacción con la facultad a través del compromiso académico, así como el efecto directo de la percepción de apoyo a la autonomía por los profesores sob…
La motivation des étudiants à l’entrée à l’université : quels effets directs ou indirects sur la réussite ?
2015
L’enjeu de cet article réside dans la mesure du rôle des capacités motivationnelles des étudiants sur la réussite universitaire, en adoptant une démarche quantitative et intégrative. À cette fin, les données récoltées sur des étudiants en première année de licence de trois filières permettent de contrôler un ensemble de facteurs relatifs aux caractéristiques socio-démographiques et scolaires des étudiants. Mesurée dans le cadre de la théorie de l’autodétermination, il ressort des analyses que la motivation intrinsèque exerce une influence positive tandis que l’amotivation se traduit par de moins bonnes performances. Par ailleurs, la motivation est un atout pour les bons étudiants, mais ne j…
Persistent and recurrent achalasia after Heller myotomy: analysis of different patterns and long-term results of reoperation.
2007
Hypothesis Two groups of patients with inadequate therapeutic success after surgical treatment for achalasia can be identified, patients with type 1 recurrence (early recurrence after technical failure of myotomy or a scarring process requiring remyotomy) and patients with type 2 recurrence (late recurrence with irreversible progression of the disease and development of megaesophagus requiring esophagectomy). Design Prospective study. Setting University-based tertiary care center. Patients One hundred sixty-three patients undergoing surgery for achalasia during 20.3 years. Interventions Conventional remyotomy for type 1 recurrence (group 1) and esophagectomy (transhiatal or transthoracic) f…
Long-term results of conventional myotomy in patients with achalasia: a prospective 20-year analysis.
2006
Myotomy has proved to be an efficient primary therapy in patients with achalasia, especially in younger patients (<40 years of age). The results of laparoscopic myotomy cannot be finally assessed, on account of the shorter postoperative follow-up. Thus, there are considerable data regarding intermediate-term outcomes after laparoscopic myotomy. The aim of our study was a 20-year analysis of the conventional cardiomyotomy as the underlying basis assessing the results of minimal-invasive surgery. Within 20 years (September 1985 through September 2005), 161 operations for achalasia were performed in our clinic. Enrolled in this study were 108 patients with a conventional, transabdominal myotom…
Effects of pneumatic dilation and myotomy on esophageal function and morphology in patients with achalasia.
2005
Only two treatment modalities–pneumatic dilation and Heller myotomy–promise long-term relief from dysphagia and regurgitation in patients with achalasia. The objective of this study was to determine whether both options differ in their effects on esophageal function, morphology, and improvement in symptoms. Eighty-nine patients diagnosed with achalasia between January 1980 and December 2002 at a single center were enrolled in this study. Sixty-four patients underwent pneumatic dilation and 25 Heller myotomy in combination with an anterior semifundoplication (Dor procedure). Clinical evaluation (Eckardt-Score), esophageal manometry, and barium swallow were performed before and within 6 mont…
Impact of Minimally Invasive Surgery in the Spectrum of Current Achalasia Treatment Options
2011
Minimally invasive Heller myotomy has evolved the “gold standard” procedure for achalasia in the spectrum of current treatment options. The laparoscopic technique has proved superior to the thoracoscopic approach due to improved visualization of the esophagogastric junction. Operative controversies most recently include the length of the myotomy, especially of its fundic part, with respect to the balance between postoperative persistent dysphagia and development of gastroesophageal reflux, as well as the type of the added antireflux procedure. Perioperative mortality should approach 0%, and favorable long-term results can be achieved in > 90%.
Reading and math abilities of Finnish school beginners born very preterm or with very low birth weight
2017
Reading and math skills of preterm born (birth weight 1500 g or gestational age:532 weeks) children and full term (FT) children were compared during the first weeks of grade 1. The participants were 194 preterm born and 175 FT children born between 2001 and 2006. There were more precocious readers among FT than among preterm students, but even the latter performed close to the national norm. FT and preterm group differences among non-readers were minor with only rapid naming showing a robust difference. Math performance showed a stable difference in favor of FT students and the difference was sustained in the full-scale IQcontrol. Major brain pathology increased the likelihood of poor schol…
LaCoDa: Layered connected topology for massive data centers
2017
One of the fundamental challenges of existing data centers is to design a network that interconnects massive number of servers, and therefore providing an efficient and fault-tolerant routing service to upper-layer applications. Several solutions have been proposed (e.g. FatTree, DCell and BCube), however they either scale too fast (i.e., double exponentially) or too slow. This paper proposes a new data center topology, called LaCoDa, that combines the advantages of previous topologies while avoiding their limitations. LaCoDa uses a small node degree that matches physical restriction for servers, and it also interconnects a large number of servers while reducing the wiring complexity and wi…