Search results for " ADR."
showing 10 items of 284 documents
Beta-3 adrenergic receptor overexpression reverses aortic stenosis-induced heart failure and restores balanced mitochondrial dynamics
2022
25 p.-7 fig.
Contrasting shell growth strategies in two Mediterranean bivalves revealed by oxygen-isotope ratio geochemistry: The case of Pecten jacobaeus and Gly…
2019
International audience; High-resolution stable-isotope ratio data (delta O-18, delta O-18) were used to study growth strategies of two bivalve species, Pecten jacobaeus (calcitic shell) and Glycymeris pilosa (aragonitic shell) from the North Adriatic Sea. The principal objectives of this study were to identify the period of the year when the growth line is formed in the shell of two target species, to identify the main growing season of these two species, to identify the environmental drivers of shell growth, and to evaluate the potential applicability of delta O-18 and delta O-18 values for the reconstruction of environmental variability. Samples were collected from the North Adriatic Sea …
Genetic architecture of the marbled goby Pomatoschistus marmoratus (Perciformes, Gobiidae) in the Mediterranean Sea
2011
The marbled goby Pomatoschistus marmoratus, a species inhabiting coastal Mediterranean lagoons, has been studied by measuring its mitochondrial DNA variation. This analysis revealed a Mediterranean west vs east split and, subsequently, an eastern differentiation among the Libyan–Tunisian Gulf, the Adriatic Sea and the Aegean Sea. The high cohesion between the samples collected in the vast area of western Mediterranean contrasts with the genetic mosaic of the more sub-structured eastern Mediterranean. This western homogeneity can not yet be fully explained even if a human-mediated migratory flow, due to a maritime traffic, has been posited. The pattern in the eastern basin revealed a genetic…
Trace and minor element records in aragonitic bivalve shells as environmental proxies
2019
Abstract Investigation of the geochemical composition of bivalve shells can provide information on changes in the marine environment occurring during the lifespan of an organism. Three species, locally abundant in the Adriatic Sea, were chosen in this study, namely Glycymeris pilosa, Callista chione, and Venus verrucosa. Of these, G. pilosa has the longest lifespan, exceeding 50 years, and therefore presents a potential archive of decadal climate variability. The other two species, C. chione and V. verrucosa, are commercially important. Samples were collected alive by SCUBA diving in the North Adriatic Sea, near Barbariga, Istria. Major growth increments in these shells form on an annual ba…
Molecular connectivity to find β-blockers with low toxicity
1997
Abstract Molecular connectivity has been used to find new β-blocker drugs using linear discriminant analysis and connectivity functions with different topological descriptors. Among the selected compounds stands out the probucol and the β-carotene. Both of them interact with β adrenoceptors.
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?
2007
International audience; The management of premature birth still remains unsatisfactory. Since the relative lack of efficiency and/or safety of current tocolytic agents have been highlighted, it is necessary to develop new uterorelaxant drugs deprived of important maternal and foetal side effects. Our work reported in this review focuses on a potential new target for tocolytic drugs, the beta3-adrenoceptor (ADRB3). This third type of ADRB is shown to be present and functional in human myometrium. We demonstrated that ADRB3 agonists are able to inhibit in-vitro spontaneous contractions of myometrial strips, via a cyclic AMP-mediated pathway. Furthermore, we established that ADRB3 is the predo…
Adrenal myelolipoma associated with adenoma
2004
The association of an adrenal myelolipoma with a non-functioning adenoma is very rare. Herein, we report on such a case in an asymptomatic 64-year-old woman. To the best of our knowledge, there is only one other case of non-functioning adrenocortical adenoma associated with myelolipoma in the same gland. Furthermore, only two other adenomas (mineral corticoids and corticosteroid producing tumors) associated with myelolipomas have been reported, and both myelolipomas were less than 1 cm in size. In conclusion, the 8.5 cm myelolipoma in our case is the largest compared with the three previously reported ones.
IP adrešu skenēšanas, apkopošanas un salīdzināšanas sistēma
2022
Darba vidē nereti ir situācijas, kad IT darbinieki nespēj izsekot līdzi visām uzņēmumam piederošajām IP adresēm, apakštīkliem, kuros var veidoties tīmekļa resursi. Kvalifikācijas darba mērķis ir izveidot sistēmu, kura paātrinās un atvieglos darbu. Sistēma tiks bāzēta uz nmap, tā veiks regulāru skenēšanu konkrētām IP adresēm un apakštīkliem, saglabās skenēšanas rezultātus datubāzē un noteiktā laika posmā salīdzinās ar iepriekš iegūtiem rezultātiem. Savukārt, ja nepieciešams uzzināt informāciju par IP adresi, to varēs viegli izdarīt, jo skenēšana tai jau būs veikta un varēs apskatīt tās vēsturi. Galvenie šī darba uzdevumi ir veikt padziļinātu izpēti par pašreizējo vidi, kurā sistēma tiks ievi…
Treatment of skeletal impairment in patients with endogenous hypercortisolism: when and how?
2014
Guidelines for the management of osteoporosis induced by endogenous hypercortisolism are not available. Both the American College of Rheumatology and the International Osteoporosis Foundation recommend to modulate the treatment of exogenous glucocorticoid-induced osteoporosis (GIO) based on the individual fracture risk profile (calculated by FRAX) and dose of glucocorticoid used, but it is difficult to translate corticosteroid dosages to different degrees of endogenous hypercortisolism, and there are no data on validation of FRAX stratification method in patients with endogenous hypercortisolism. Consequently, it is unclear whether such recommendations may be adapted to patients with endoge…
"Io son l'umile ancella del genio creator...". Percorsi di Francesco Cilea dal teatro verista ad "Adriana Lecouvreur"
2020
Il saggio delinea i percorsi biografici e artistici di Francesco Cilea, nel contesto della cultura italiana fra Otto e Novecento e con particolare riferimento alla fonte letteraria, alla genesi, ai personaggi, alla drammaturgia e al carattere musicale dell'opera in quattro atti "Adriana Lecouvreur" (1902).