Search results for " AGI"
showing 10 items of 672 documents
La tutela dei creditori nel caso di confisca per misura di prevenzione: le novità introdotte dalla Legge di stabilità 2013
2013
L'articolo esamina gli strumenti di tutela in favore dei creditori, nel caso in cui i beni del debitore sono oggetto di misura di prevenzione patrimoniale: sequestro o confisca.
Mitochondria as sources and targets of damage in cellular aging.
2011
Mitochondria are considered as the most important cellular sources and targets of free radicals. They are also a source of signalling molecules that regulate cell cycle, proliferation, and apoptosis. Denham Harman postulated the free radical theory of aging in 1956. Previously Rebecca Gershman showed that radiation toxicity could be attributed to free radical damage. Subsequently, Jaime Miquel formulated the mitochondrial free radical theory of aging. We have shown that mitochondrial size, membrane potential, inner membrane mass and peroxide production is altered inside cells in old animals. These result in an increase in the oxidative damage to mitochondrial DNA with aging that can be prev…
Synthesis, physicochemical characterization, cytotoxicity, antimicrobial, anti-inflammatory and psychotropic activity of new N-[1,3-(benzo)thiazol-2-…
2012
Abstract A series of new N-[(benzo)thiazol-2-yl]-2/3-[3,4-dihydroisoquinolin-2(1H)-yl]ethan/propanamide derivatives was synthesized and characterized by 1H, 13C NMR and IR spectroscopy and mass-spectrometry. A single crystal X-ray study of N-(1,3-benzothiazol-2-yl)-2-[3,4-dihydroisoquinolin-2(1H)-yl]ethanamide is reported to determine its conformational feature. The investigated compounds were found to be active in psychotropic in vivo, anti-inflammatory in vivo and cytotoxicity in vitro screening. They possess marked sedative action, reveal high anti-inflammatory activity, have selective cytotoxic effects and NO-induction ability concerning tumour cell lines. Some of the compounds synthesi…
Aging men, masculinities and modern medicine: An introduction
2013
This new focus on men as a research category has coincided with rapidly increasing aging populations in Western nations, with attendant concerns about the consequences for already-strained health and social service systems. World Health Day in 20 12, for example, focused on the theme of aging and health, aiming no less than for a 'need to reinvent aging' (WHO 2012) . Since the late 1990s, the 'aging male' in particular has become the focus of an expanding constellation of professional and health promotion concerns. As the mission statement of the International Society for the Study of the Aging Male put it, 'healthy aging and survival of men will have an impact on both family and society. T…
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
2020
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1, PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank p…
Biomarkers and Inflammatory Network in Aging
2014
Abstract Humans are characterized by a large heterogeneity in lifespans. The aging rate, measured as a decline of functional capacity and stress resistance, is different in every individual. Several attempts have been made to define the so-called biological age, but without achieving real success. Biomarkers of aging, which are represented by biological indicators selected using appropriate criteria, should help to characterize the biological age. Since age is a major risk factor in many degenerative diseases, such biomarkers could subsequently be used to identify individuals at a high risk of developing age-associated diseases or disabilities. In this chapter, some inflammatory biomarkers …
Le commissaire à l'exécution d'un plan de cession n'a pas qualité pour engager une action en nullité des paiements ou des actes faits durant la pério…
2008
International audience; (Com. 13 nov. 2007, pourvoi n° 05-13.248, arrêt n° 1248 FS-P+B+R+I, Meynet, ès qual. c/ Banque de Savoie, Bull. civ. IV, n° 243 ; D. 2007. AJ. 3010, obs. A. Lienhard ; D. 2008. Pan. 570, spéc. 573, obs. F.-X. Lucas ; JCP 2008. I. 142, n° 7, obs. M. Cabrillac ; Rev. proc. coll. 2008, n° 2, p. 57, obs. G. Blanc ; Defrénois 2008. 1223, note D. Gibirila)
Période suspecte. Annulation d'un acte accompli en période suspecte. Nullité invoquée par un tiers. Conditions
1999
International audience; (Com. 3 juin 1997, Caisse de crédit mutuel Angers-Anjou c/ Guestault et autre)
Action en nullité de la période suspecte. Défaut de qualité du débiteur à agir
2015
International audience; (Com., 2 décembre 2014, n° 13-24.308, arrêt n° 1074 F-P+B, Sté CIEC c/ Sté Carlson, D. 2014. 2518)
Effect of storage on quality parameters and phenolic content of Italian extra-virgin olive oils
2019
The quality of extra virgin olive oils is affected mainly by hydrolytic and oxidative reactions. The present paper investigated the changes of major and minor components and oxidation indices of three monovarietal extra virgin olive oils after 18 months of storage at room temperature and in dark glass bottles conditions. After storage, the basic quality parameters such as free acidity, peroxide values, extinction coefficients, fatty acids composition, chlorophyll and carotenoid content, did not exceed the upper limits set by European Community Regulations for extra-virgin olive oils. Given the importance of the phenolic fraction, UHPLC-HESI-MS metodology was used. A decrease in 3,4-DHPEA-ED…