Search results for " ASSOCIATION"
showing 10 items of 996 documents
Genome-Wide Expression Profiles in Very Low Birth Weight Infants With Neonatal Sepsis
2014
BACKGROUND: Bacterial sepsis is associated with high morbidity and mortality in preterm infants. However, diagnosis of sepsis and identification of the causative agent remains challenging. Our aim was to determine genome-wide expression profiles of very low birth weight (VLBW) infants with and without bacterial sepsis and assess differences. METHODS: This was a prospective observational double-cohort study conducted in VLBW (<1500 g) infants with culture-positive bacterial sepsis and non-septic matched controls. Blood samples were collected as soon as clinical signs of sepsis were identified and before antibiotics were initiated. Total RNA was processed for genome-wide expression an…
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium
2011
Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of RO…
DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma
2019
A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or innate immunity plays a role in the obesity-asthma link. DNA methylome was measured in blood samples of 61 non-atopic participants with asthma and 146 non-atopic participants without asthma (non-smokers for at least 10 years) taking part in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) study. Modification by DNA methylation of the association of BMI or BMI change over 10 years with adult-onset asthma was examined at each CpG sit…
Rubinstein–Taybi syndrome 2 with cerebellar abnormality and neural tube defect
2019
Rubinstein-Taybi syndrome (RSTS) is a rare dominant disorder with intellectual disability, postnatal growth deficiency, and multiple congenital anomalies. Approximately 50-70% of the patients have a mutation in the CREBBP gene (RSTS1) and 5-10% display an EP300 gene mutation (RSTS2). Craniospinal abnormalities such as microcranium, scoliosis, and lordosis are frequent findings in RSTS1, but malformations of the brain or spinal cord are seen only occasionally. Here, we report on a 3-year-old boy with facial abnormalities of RSTS, broad thumbs and halluces, developmental delay, autistic features, cerebellar underdevelopment, and a neural tube defect. Molecular diagnostic of the CREBBP and EP3…
Association Mapping Based on a Common-Garden Migration Experiment Reveals Candidate Genes for Migration Tendency in Brown Trout
2019
A better understanding of the environmental and genetic contribution to migratory behavior and the evolution of traits linked to migration is crucial for fish conservation and fisheries management. Up to date, a few genes with unequivocal influence on the adoption of alternative migration strategies have been identified in salmonids. Here, we used a common garden set-up to measure individual migration distances of generally highly polymorphic brown trout Salmo trutta from two populations. Fish from the assumedly resident population showed clearly shorter migration distances than the fish from the assumed migratory population at the ages of 2 and 3 years. By using two alternative analytical …
The practice-driven evolution of family business education
2007
Abstract Starting from Calder's dissertation in the early fifties, key developments in family business education are presented in a 130-item chronology. The emergence of the field is tracked to the demand from practitioners rather than the pull of scholarly inquiry. Causal evolutionary drivers of variation, selective retention, and struggle for survival, provide a framework for understanding the past and current status of the knowledge base for family business and hinting at future development. The critical role of infrastructure – family business centers and professional associations – is evident in the path dependent evolution and growth of the field. Although the last two decades have wi…
Crystallinity of block copolymer controlled by cyclodextrin
2018
We report a differential scanning calorimetry study to investigate the effect of cyclodextrins (CD) on the crystallinity of a copolymer. Tetronics was selected as copolymer with star-like shape formed by four polyethylene oxide flanked by four polypropylene oxide blocks linked to ethylenediamine central group. The use of CD with different cavity size was exploited for a block selective inclusion. A model for supramolecular association was considered for a quantitative description of the enthalpy data. The polymer chain incorporation into the CD cavity generates a loss of crystallinity. The stoichiometry of the CD/copolymer aggregates can be tuned by changing the CD cavity size. The investig…
Computational Study of Association of Dihydroxybenzoic Acids in Solution: Testing the Molecular Self-Association Computational Methodology for Format…
2020
Already validated methodology for self-association in solutions were used to evaluate if this method could also be used in other studies regarding association in solution. Three isomeric dihydroxybenzoic acids were used to calculate Gibbs free energies of association for homodimers, heterotetramers and associates with solvent molecules by using DFT calculations in multiple environments and having different conformations.
Developmental dynamics between children’s externalizing problems, task-avoidant behavior, and academic performance in early school years: A 4-year fo…
2015
This longitudinal study investigated the associations among children’s externalizing problems, task-avoidant behavior, and academic performance in early school years. The participants were 586 children (43% girls, 57% boys). Data pertaining to externalizing problems (teacher ratings) and task-avoidant behaviors (mother and teacher ratings) were gathered, and the children were tested yearly on their academic performance in Grades 1–4. The results were similar for both genders. The analyses supported a mediation model: high externalizing problems in Grades 1 and 2 were linked with low academic performance in Grades 3 and 4 through increases in task-avoidant behavior in Grades 2 and 3. The res…
Curb your neuroticism – Mindfulness mediates the link between neuroticism and subjective well-being
2015
Abstract Recent research has shown that mindfulness moderates the negative emotional reactivity associated with neuroticism. In two studies, we investigated how neuroticism and mindfulness are associated with subjective well-being (SWB), assuming a moderated mediation. In Study 1, 147 participants (74.2% female, M = 34.3 years, SD = 11.9) completed an online survey. Mindfulness partially mediated but did not moderate the relationship between neuroticism and SWB, indicating that low levels of mindfulness were partially accountable for lower SWB in individuals high in neuroticism. In Study 2, 108 participants (80.6% female, M = 25.2 years, SD = 6.6) completed daily diaries for 6 days. We …