Search results for " ASSOCIATION"
showing 10 items of 996 documents
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
2009
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the 7600 most associated SNPs from the first stage in three independent cohorts consisting of 2160 cases and 3008 controls. None of the SNPs selected for replication exceeded the Bonferroni threshold for significance. The two most significantly associated SNPs, rs2708909 and rs2708851 …
Enroling around : Reconfiguring place and space in the wake of a new reception centre in a small rural town
2022
The paper examines how a small rural town Kauhava, Finland, is reconfigured in the wake of a reception centre being established. Drawing on the conceptual toolbox of the sociology of associations, we find that regardless of attitudes towards asylum seekers, people springing into action and enroling others leads to the problematisation and intensification of place. This involves turning public and private spaces into contested places. Competing definitions of community and identity emerge. While new identities are configured, new associations and ways of linking actors and places together also take form. The paper examines how the micropolitics of place and belonging are carried out in pract…
The Gaia-ESO Survey: The origin and evolution of s-process elements
2018
Context. Several works have found an increase of the abundances of the s-process neutron-capture elements in the youngest Galactic stellar populations. These trends provide important constraints on stellar and Galactic evolution and they need to be confirmed with large and statistically significant samples of stars spanning wide age and distance intervals. Aims. We aim to trace the abundance patterns and the time evolution of five s-process elements - two belonging to the first peak, Y and Zr, and three belonging to the second peak, Ba, La, and Ce - using the Gaia-ESO IDR5 results for open clusters and disc stars. Methods. From the UVES spectra of cluster member stars, we determined the ave…
Gaia-ESO Survey: Global properties of clusters Trumpler 14 and 16 in the Carina nebula
2017
Aims: We present the first extensive spectroscopic study of the global population in star clusters Trumpler 16, Trumpler 14, and Collinder 232 in the Carina nebula, using data from the Gaia-ESO Survey, down to solar-mass stars. Methods: In addition to the standard homogeneous survey data reduction, a special processing was applied here because of the bright nebulosity surrounding Carina stars. Results: We find about 400 good candidate members ranging from OB types down to slightly subsolar masses. About 100 heavily reddened early-type Carina members found here were previously unrecognized or poorly classified, including two candidate O stars and several candidate Herbig Ae/Be stars. Their l…
The Gaia-ESO Survey: Structural and dynamical properties of the young cluster Chamaeleon i
2017
Investigating the physical mechanisms driving the dynamical evolution of young star clusters is fundamental to our understanding of the star formation process and the properties of the Galactic field stars. The young (~2 Myr) and partially embedded cluster Chamaeleon I is one of the closest laboratories for the study of the early stages of star cluster dynamics in a low-density environment. The aim of this work is to study the structural and kinematical properties of this cluster combining parameters from the high-resolution spectroscopic observations of the Gaia-ESO Survey with data from the literature. Our main result is the evidence of a large discrepancy between the velocity dispersion …
Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link
2021
Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent chronic autoimmune diseases worldwide. Several autoimmune endocrine and non-endocrine disorders tend to occur together. T1D and AITD often cluster in individuals and families, seen in the formation of autoimmune polyendocrinopathy (AP). The close relationship between these two diseases is largely explained by sharing a common genetic background. The HLA antigens DQ2 (DQA1*0501-DQB1*0201) and DQ8 (DQA1*0301-DQB1*0302), tightly linked with DR3 and DR4, are the major common genetic predisposition. Moreover, functional single nucleotide polymorphisms (or rare variants) of various genes, such as the cytotoxic T-lym…
Rola serwisu internetowego w promocji działalności towarzystw bibliofilskich
2007
Towarzystwa bibliofilskie, aby rozwijać się w XXI w., muszą dotrzeć do społeczeństwa za pomocą Internetu. Obecnie dużą rolę w propagowaniu działalności na polu miłośnictwa książek odgrywa posiadanie własnego serwisu WWW. W artykule uzasadniono potrzebę promocji towarzystw bibliofilskich w Internecie. Omówiono skuteczność wykorzystania w tym celu serwisu internetowego. Przedstawiono możliwości jego zastosowania w działalności promocyjnej oraz public relations na przykładzie serwisu Rycerskiego Zakonu Bibliofilskiego z Kapitułą Orderu Białego Kruka w Krakowie, który powstał w ramach pracy magisterskiej autorki artykułu. Omówiono projekt serwisu oraz etapy jego tworzenia. Przedstawiono wyniki …
Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample…
2022
This work was supported by funding from the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). (...) CA was supported by the Spanish Ministry of Science and Innovation; Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), Fundación Familia Alonso and Fundación Alicia Koplowitz. MB was supported by the Ministry of Economy and Competitivity (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III – ERDF Funds from the European Commission, ‘A way of making Europ…
Correlations of isokinetic and psychophysical back lift and static back extensor endurance tests in men
1994
Isokinetic lift, psychophysical lift, and static back endurance tests are among the most widely used measurements of muscle function for determining risk for, and recovery from, back problems. After determining test repeatability we examined the degree of association between these test measures in 100 men selected to represent a variety of occupations and lifestyles. Isokinetic lifting had low correlations with test results for psychophysical lifting (r = 0.28) and static back endurance (r = 0.24). Static back endurance and psychophysical lift test results were not at all correlated (r = 0.03). RELEVANCE--:Muscle function measurements for back problems are sometimes arbitrarily selected due…
Prediction of Disease–lncRNA Associations via Machine Learning and Big Data Approaches
2021
This chapter introduces long non-coding RNAs and their role in the occurrence and progress of diseases. The discovery of novel lncRNA-disease associations may provide valuable input to the understanding of disease mechanisms at the lncRNA level, as well as to the detection of biomarkers for disease diagnosis, treatment, prognosis, and prevention. Unfortunately, due to costs and time complexity, the number of possible disease-related lncRNAs verified by traditional biological experiments is very limited. Computational approaches for the prediction of potential disease-lncRNA associations can effectively decrease the time and cost of biological experiments. We first review the main computatio…