Search results for " Aging"
showing 10 items of 584 documents
Oxidative stress and mitochondrial dysfunction in Kindler syndrome
2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.
The effect of Transient over Voltages on the Partial Discharges activity in HVDC joints
2021
Rapid growth of HVDC cable line installations is expected in the coming years. Several research groups have investigated dielectric phenomena that occur in the insulation of HVDC cables and accessories that accelerate aging and reduce the reliability of this technology over time. Unlike in HVAC cables, under HVDC stress, the distribution of the electric field inside the insulation layer depends not only on the applied voltage but also on the temperature distribution and on other factors related to manufacturing such as the presence of impurities. Reaching local and transient electric field peaks can enhance the onset of Partial Discharges (PDs) which can lead to premature aging of the insul…
Release and permeation profiles of spray-dried chitosan microparticles containing caffeic acid
2018
Made available in DSpace on 2018-12-11T17:17:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01 Caffeic acid (CA), a phenolic compound found in plants with antioxidant and antimicrobial activity, induces collagen production and prevents premature aging of the skin. The objective of this study was to develop two types of chitosan microparticles (MP) containing CA and to relate the morphology with the release and permeation profiles. One type of MP was prepared from a hydroalcoholic solution (MPI) and the other from an aqueous solution (MPII). Their morphology and size was evaluated by high-resolution scanning electron microscopy. The release profile of CA was evaluated using the…
Cognitive impairment and stroke in elderly patients.
2016
Daniele Lo Coco,1 Gianluca Lopez,1 Salvatore Corrao,2,31Neurology and Stroke Unit, 2Department of Internal Medicine, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, 3Centre of Research for Effectiveness and Appropriateness in Medicine (C.R.E.A.M.), Di.Bi.M.I.S., University of Palermo, Palermo, Italy Abstract: We reviewed current knowledge about the interaction between stroke and vascular risk factors and the development of cognitive impairment and dementia. Stroke is increasingly recognized as an important cause of cognitive problems and has been implicated in the development of both Alzheimer's disease and vascular dementia. Th…
Phenols content and 2-D electrophoresis protein pattern: a promising tool to monitor Posidonia meadows health state
2007
Abstract Background The endemic seagrass Posidonia oceanica (L.) Delile colonizes soft bottoms producing highly productive meadows that play a crucial role in coastal ecosystems dynamics. Human activities and natural events are responsible for a widespread meadows regression; to date the identification of "diagnostic" tools to monitor conservation status is a critical issue. In this study the feasibility of a novel tool to evaluate ecological impacts on Posidonia meadows has been tested. Quantification of a putative stress indicator, i.e. phenols content, has been coupled to 2-D electrophoretic protein analysis of rhizome samples. Results The overall expression pattern from Posidonia rhizom…
The regulation of emotions: Gender differences
2021
IntroductionEmotional regulation, understood as the emotional ability to repair emotional states, is a skill closely linked to adaptation during aging. People who are capable to manage their emotions have greater control over moods, applying adaptive regulation strategies that allow them to maintain positive moods and modify or regulate negative ones. It has been observed that gender can be a relevant variable related to emotional regulation. In this sense, it is considered that women may be more skillful than men to emotional regulation strategies, benefiting from more successful emotional management strategies.ObjectivesVerify if there are differences in the ability of emotional regulatio…
Smoking and Obesity Increase Airway Hyperesponsiveness Risk In the Elderly
2015
Objective of our study was assessing whether smoking and obesity might affect airways hyperresponsiveness (AHR) differently in younger and older subjects and whether this influence might be due to their different impacts on baseline lung function values at different ages. Methods 3,903 consecutive adult subjects with normal lung function (1,920 males; mean age 35.1±16.2; median FEV1:97.3% of predicted [interquartile range (IQR):89.7-105.2] and FEV1/FVC:84.6% of predicted [IQR:79.8-89.2]), having performed a methacholine test, were considered. They were subdivided into three groups according to age (18-39, 40-64 and ≥65 years) and into different sub-groups according to body mass index (BMI) …
Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics
2003
In asthmatic subjects an imbalance between elastase and alpha1-antitrypsin (alpha1-PI) exists. This study aims to evaluate whether ageing per se affects the levels of elastase. Both young and elderly asthmatics with comparable severity and duration of disease, as well as young and elderly healthy subjects, underwent an induced sputum procedure to measure levels of elastase and alpha1-PI. The percentage of sputum neutrophils and eosinophils was higher in young and elderly asthmatics than in young and elderly controls. The levels of both total and active elastase were significantly higher in young and elderly asthmatics than in young and elderly controls, and directly correlated with the perc…
Clinical implications of airway hyper-responsiveness in COPD
2006
COPD represents one of the leading causes of mortality in the general population. This study aimed at evaluating the relationship between airway hyperresponsiveness (AHR) and COPD and its relevance for clinical practice. We performed a MEDLINE search that yielded a total of 1919 articles. Eligible studies were defined as articles that addressed specific aspects of AHR in COPD, such as prevalence, pathogenesis, or prognosis. AHR appears to be present in at least one out of two individuals with COPD. The occurrence of AHR in COPD is influenced by multiple mechanisms, among which impairment of factors that oppose airway narrowing plays an important role. The main determinants of AHR are reduct…
Validation of FEV6 in the elderly: correlates of performance and repeatability.
2007
BACKGROUND: Forced expiratory volume in 6 s (FEV6) has been proposed as a more easily measurable parameter than forced vital capacity (FVC) to diagnose airway disease using spirometry. A study was undertaken to estimate FEV6 repeatability, to identify correlates of a good quality FEV6 measurement and of volumetric differences between FEV6 and FVC in elderly patients. METHODS: 1531 subjects aged 65-100 years enrolled in the SA.R.A project (a cross-sectional multicentre non-interventional study) were examined. FEV6 was measured on volume-time curves that achieved satisfactory start-of-test and end-of-test criteria. Correlates of FEV6 achievement were assessed by logistic regression. RESULTS: …