Search results for " Aging"

Conclusions. Slowing aging and fighting age-related diseases, from bench to bedside?

2021

Abstract The multiple wide-ranging and diverse aspects of aging discussed in this volume are overviewed and integrated in order to move toward a better understanding of how to achieve successful aging. To this end, potential strategies capable of slowing aging and preventing age-related diseases are considered and actions proposed.

AORTIC STIFFNESS IS INCREASED IN NORMOTENSIVE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2018

INTRODUCTION: Patients with systemic lupus erythematosus (SLE) have a 4- to 10-fold increased risk of developing cardiovascular (CV) events compared with the general population. The enhanced CV risk conferred by SLE may in part be mediated through preclinical CV damage. Large artery stiffness is usually assessed by measuring aortic pulse wave velocity (aPWV), a marker of early vascular aging (EVA) and an independent predictor of adverse CV prognosis. Several studies examined aortic stiffness in SLE with inconsistent results. AIM: To evaluate aPWV and the prevalence of EVA in a group of normotensive patients with SLE and to compare these values with those obtained in age- and gender- matched…

Magnesium and Type 2 Diabetes: An Update

2015

The link between magnesium (Mg) deficiency and type 2 diabetes mellitus is well known. Type 2 diabetes is frequently associated with both extracellular and intracellular Mg deficits. A chronic latent Mg deficit or an overt clinical hypomagnesaemia is common in subjects with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistanc…

The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men

2014

The role of nutritional status as determinant of successful aging is very well recognized. There is recent evidence that nutrition may exert its beneficial effects through the modulation of the hormonal anabolic milieu. Under-nutrition and anabolic hormonal deficiency frequently coexist in older individuals determining an increased risk of mobility impairment and adverse outcomes. Mineral dietary assessment has received attention as key component of the nutritional modulation of anabolic status and physical performance. There is evidence that several minerals, including magnesium, exert a positive influence on Insulin-like Growth Factor-1 (IGF-1) secretion in both sexes, and Testosterone (T…

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart diseas…

2013

AIMS: The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD).METHODS AND RESULTS: Of the theoretical estimated prevalence of 1/500 for heterozygous FH, <1% are diagnosed in most countries. Recently, direct screening in a Northern European general population diagnosed approximately 1/200 with heterozygous FH. All reported studies document failure to achieve recommended LDL cholesterol targets in a large proportion of individuals with FH, and up to 13-fold increased risk of CHD. Based on prev…

Relationship between lower limb position and pelvic floor muscle surface electromyography activity in menopausal women: a prospective observational s…

2017

Tomasz Halski,1 Kuba Ptaszkowski,2 Lucyna Słupska,1 Robert Dymarek,3 Małgorzata Paprocka-Borowicz2 1Department of Physiotherapy, Opole Medical School, Opole, 2Department of Clinical Biomechanics and Physiotherapy in Motor System Disorders, 3Department of Nervous System Diseases, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland Objectives: In physiotherapeutic practice, special attention is being given to the reciprocal anatomical, physiological, and biomechanical relationship of the pelvis and the structures connected to it. However, the scientific literature shows mainly the theoretical information about their mutual connections. The lack of information about these …

Selected Age-Related Disorders

2013

Aged human individuals are frequently affected by various age-related impairments and disorders at once (multimorbidity) making it difficult to investigate and understand the link between aging as key risk factor and single syndromes. In some chapters of this book links have been identified between molecular mechanisms of aging and the pathogenesis of human disorders in the elderly. Here, the focus is put on Alzheimers disease (AD) and cancer. While cancer in many cases can successfully be treated and sometimes even cured by pharmacology and/or surgery, AD is still an incurable deadly disease. Like almost no other disorder the onset of AD is strictly associated with higher age and experienc…

Behavioral and hemodynamic effects of prefrontal anodal stimulation in healthy older adults: a simultaneous tDCS/fNIRS study

2019

Evaluating resurfacing modalities in aesthetics.

2022

Abstract Skin resurfacing for cutaneous rejuvenation has evolved with the development of a plethora of nonsurgical and minimally invasive modalities. We have highlighted the advances in laser therapy, chemical peels, radiofrequency, microneedling, and platelet-rich plasma therapy. We have also included studies providing head-to-head comparisons between procedures and discussed relevant debates in the field. We have examined additionally combination treatments and resurfacing in acne scars, melasma, and skin of color.

Exploring Potential Benefits of Accumulated Multicomponent-Training in Non-Active Older Adults: From Physical Fitness to Mental Health

2021

The present study aimed to analyze the impact of a multicomponent training (MCT) program in a group of non-active older adults, comparing two different dose distributions. Twenty-four individuals, assigned to two groups, completed 15 weeks of MCT (2 days/week). The continuous group (CMCT