Search results for " Alzheimer disease"

showing 10 items of 38 documents

Oxidative stress in patients with Alzheimer's disease: Effect of extracts of fermented papaya powder

2015

Brain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer’s disease (AD). Postmortem studies in AD patients’ brains have shown oxidative damage markers (i.e., lipid peroxidation, protein oxidative damage, and glycoxidation). Fermented papaya (FPP, a product ofCarica papaya Linnfermentation with yeast) is a nutraceutical supplement with favorable effects on immunological, hematological, inflammatory, and OS parameters in chronic/degenerative diseases. We studied 40 patients (age 78.2 ± 1.1 years), 28 AD patients, and 12 co…

MaleAntioxidantSettore MED/09 - Medicina Internamedicine.medical_treatmentReview Articlemedicine.disease_causeAntioxidantsLipid peroxidationchemistry.chemical_compoundchemistry.chemical_classificationAged 80 and overbiologyCaricaBrainBiochemistry8-Hydroxy-2'-DeoxyguanosineFemalePowdersCaricaAlzheimer's diseaseAntioxidantCase-Control StudieReactive Oxygen SpecieOxidation-Reductionlcsh:RB1-214Humanmedicine.medical_specialtyUrinary systemImmunologyPowderAlzheimer DiseaseInternal medicinemedicinelcsh:PathologyHumansAgedDietary SupplementReactive oxygen speciesCase-control studyDeoxyguanosineOxidative StrePlant PreparationCell Biologybiology.organism_classificationmedicine.diseaseAged; Aged 80 and over; Alzheimer Disease; Antioxidants; Brain; Carica; Case-Control Studies; Deoxyguanosine; Dietary Supplements; Female; Fermentation; Humans; Lipid Peroxidation; Male; Oxidation-Reduction; Oxygen; Plant Preparations; Powders; Reactive Oxygen Species; Oxidative Stress; Immunology; Cell BiologyOxygenOxidative StressEndocrinologychemistryCase-Control StudiesDietary SupplementsFermentationPlant PreparationsLipid PeroxidationReactive Oxygen SpeciesOxidative stress
researchProduct

Apoe genotypes and brain imaging classes in normal cognition, mild cognitive impairment, and alzheimer’s disease: A longitudinal study

2020

Objective: To evaluate in 419 stroke-free cognitively normal subjects (CN) aged 45-82 years covering during a long prospective study (11.54 ± 1.47 years) the preclinical to dementia spectrum: 1) the distribution of small vessel disease (V) and brain atrophy (A) aggregated as following: V−/A−, V−/A+, V+/A−, V+/A+; 2) the relationship of these imaging classes with individual apolipoprotein E (APOE) genotypes; 3) the risk of progression to Alzheimer Disease (AD) of the individual APOE genotypes. Methods: Participants underwent one baseline (t0), and 4 clinical and neuropsychological assessments (t1,t2,t3, and t4). Brain MRI was performed in all subjects at t0, t2, t3 and t4.. White matter hyp…

MaleApolipoprotein Emedicine.medical_specialtyGenotypeApolipoprotein E4NeuroimagingNeuropsychological TestsAPOE genotypes Brain imaging classes Caudate atrophy Global cerebral atrophy Lacunes White matter hyperintensities Aged Aged 80 and over Alzheimer Disease Apolipoprotein E4 Apolipoproteins E Brain Case-Control Studies Cognitive Dysfunction Disease Progression Female Genotype Humans Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Neuroimaging Neuropsychological Tests Risk Factorsbrain imaging classesApolipoproteins EAtrophyNeuroimagingAlzheimer DiseaseRisk FactorsInternal medicineGlobal brain atrophymedicineHumansDementiaCognitive DysfunctionLongitudinal Studiescaudate atrophyAgedglobal cerebral atrophyAged 80 and overAPOE genotypesbusiness.industryNeuropsychologyBrainMiddle Agedwhite matter hyperintensitiesmedicine.diseaseMagnetic Resonance ImagingHyperintensityNeurologyCase-Control StudiesDisease ProgressionCardiologyFemaleNeurology (clinical)Alzheimer's diseasebusiness
researchProduct

Lexical and conceptual components of stem completion priming in patients with Alzheimer's disease

1999

This study evaluated the hypothesis of dissociation between normal lexical but deficient conceptual repetition priming in patients with Alzheimer's disease (AD). For this purpose, we administered to patients with AD and age-matched normal controls the Stem Completion task. In Experiment 1, the level of word processing during study was manipulated by requiring subjects to count vowels (graphemic condition) or generate meanings (semantic condition) of target words. In Experiment 2, the presentation modality was varied during the study to obtain an intramodal and crossmodal repetition priming. Probably due to a floor effect of performance in the graphemic condition, in Experiment 1, AD patient…

MaleDissociation (neuropsychology)Cognitive NeuroscienceConcept FormationWord processingRepetition primingExperimental and Cognitive PsychologyAssociationBehavioral NeuroscienceMemoryAlzheimer DiseasemedicineHumansMemory disorderIntramodal dispersionAgedAnalysis of VarianceAlzheimer's dementiaCrossmodalMiddle Agedmedicine.diseaseSemanticsRepetition primingAnalysis of Variance; Reading; Association; Humans; Alzheimer Disease; Aged; Mental Recall; Cognition Disorders; Semantics; Concept Formation; Speech Perception; Practice (Psychology); Cues; Case-Control Studies; Middle Aged; Female; MaleReadingPractice PsychologicalPractice (Psychology)Case-Control StudiesMental RecallSpeech PerceptionFemaleSettore MED/26 - NeurologiaImplicit memoryCuesPsychologyCognition DisordersPriming (psychology)Cognitive psychology
researchProduct

The role of mind theory in patients affected by neurodegenerative disorders and impact on caregiver burden

2020

Abstract Background Theory of Mind (ToM) is defined as the ability to understand mental and emotional state. This ability is assessed also in neurodegenerative disease. Few studies have investigated the impact that social cognition of patients could have on caregiver burden. The aim of this study was to investigate a possible correlation in level of social cognition impairment between patients with different neurodegenerative disorders and their caregivers with possible impact on caregivers burden. Methods we enrolled 48 patients with dementia divided in different groups: Fronto-Temporal Dementia (FTD), Alzheimer Disease (AD), and Mild Cognitive Impairment (MCI) and also the three groups of…

MaleEmotionsTheory of MindDiseaseFronto-temporal dementia03 medical and health sciences0302 clinical medicineSocial cognitionAlzheimer DiseasePhysiology (medical)Theory of mindmental disordersActivities of Daily Livingmedicine80 and overDementiaHumansIn patientCognitive DysfunctionAlzheimer disease; Caregiver; Dementia; Fronto-temporal dementia; Mild cognitive impairment; Theory of mind; Activities of Daily Living; Aged; Aged 80 and over; Alzheimer Disease; Caregivers; Cognitive Dysfunction; Emotions; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurodegenerative Diseases; Theory of MindAgedAged 80 and overbusiness.industryMild cognitive impairmentNeurodegenerative DiseasesGeneral MedicineCaregiver burdenMiddle Agedmedicine.diseaseCaregiverDistressNeurologyCaregivers030220 oncology & carcinogenesisFrontotemporal DementiaSurgeryDementiaFemaleNeurology (clinical)Alzheimer's diseasebusiness030217 neurology & neurosurgeryClinical psychology
researchProduct

Heterogeneity in Risk Factors for Cognitive Impairment, No Dementia: Population-Based Longitudinal Study From the Kungsholmen Project

2006

OBJECTIVES: The objectives of this study were to investigate the relation of vascular, neuropsychiatric, social, and frailty-related factors with "Cognitive impairment, no dementia" (CIND) and to verify their effect independently of future progression to Alzheimer disease (AD). METHODS: Seven hundred eighteen subjects aged 75+ years who attended baseline, 3- and 6-year follow-up examinations of the Kungsholmen Project, a Swedish prospective cohort study, were studied. CIND was defined according to the performance on the Mini-Mental State Examination. Potential risk factors were collected at baseline and clustered according to four research hypotheses (frailty, vascular, neuropsychiatric, an…

MaleLongitudinal studyPsychosisPopulationAlzheimer DiseaseRisk FactorsActivities of Daily Livingmental disordersmedicineHumansDementiaeducationProspective cohort studyAgedProportional Hazards ModelsAged 80 and overSwedenPolypharmacyeducation.field_of_studyHip fractureHip FracturesMild cognitive impairment Alzheimer disease hip fracture polypharmacy psychosismedicine.diseasePsychiatry and Mental healthPsychotic DisordersDisease ProgressionPolypharmacyFemaleSettore MED/26 - NeurologiaGeriatrics and GerontologyAlzheimer's diseaseCognition DisordersPsychologyFollow-Up StudiesClinical psychologyThe American Journal of Geriatric Psychiatry
researchProduct

''Motor Resonance Mechanisms Are Preserved In Alzheimer's Disease Patients''

2012

Bisio, A. | Casteran, M. | Ballay, Y. | Manckoundia, P. | Mourey, F. | Pozzo, T.; International audience; ''This study aimed to better characterize the sensorimotor mechanisms underlying motor resonance, namely the relationship between motion perception and movement production in patients suffering from Alzheimer's disease (AD). This work first gives a kinematic description of AD patients' upper limb movements, then it presents a simple paradigm in which a dot with different velocities is moved in front of the participant who is instructed to point to its final position when it stopped. AD patients' actions, as well as healthy elderly participants, were similarly influenced by the dot veloc…

MaleMILD COGNITIVE IMPAIRMENTData InterpretationInhibition (Psychology)DiseaseNeuropsychological TestsHUMAN AUTONOMYExecutive FunctionCognition80 and overAged 80 and overMovement observation-executionGeneral NeuroscienceMIRROR NEURONSCognitionStatisticalAction-perception matchingAction-perception matching; Ageing; Automatic imitation; Dementia; Movement observation-execution; Aged; Aged 80 and over; Alzheimer Disease; Arm; Biomechanical Phenomena; Cognition; Data Interpretation Statistical; Executive Function; Female; Humans; Inhibition (Psychology); Linear Models; Male; Movement; Neuropsychological Tests; Photic Stimulation; Psychomotor Performance; Neuroscience (all)Biomechanical PhenomenaInhibition PsychologicalSOCIAL COGNITIONData Interpretation Statistical[ SCCO.NEUR ] Cognitive science/NeuroscienceArmFemaleAlzheimer's diseasePsychologyMovementStimulus (physiology)Alzheimer DiseaseCOLOR-WORD TESTmedicineHumansDementiaREACTION-TIME''Motion perceptionREACTION-TIMENEURAL MECHANISMSMotor resonanceAgedNeuroscience (all)Healthy elderlyPOINTING MOVEMENTSmedicine.diseaseFRONTAL LOBESVISUOMOTOR INTEGRATIONAgeing''MILD COGNITIVE IMPAIRMENTLinear ModelsDementiaNeuroscienceAutomatic imitationPhotic StimulationPsychomotor Performance
researchProduct

Lymphocytic Mitochondrial Aconitase Activity is Reduced in Alzheimer's Disease and Mild Cognitive Impairment

2015

Background: Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radicalmediated damage. Objective: We assessed activity and expression of ACO2 extracted from blood lymphocytes of subjects with AD, mild cognitive impairment (MCI), older adults with normal cognition (OCN, age >= 65 years), and younger adults with normal cognition (YCN, age < 65 years). Plasma levels and activities of antioxidants were also measured. Methods: Blood samples were collected from 28 subjects with AD, 22 with MCI, 21 OCN, and 19 YCN. ACO2 act…

MalePathologyantioxidantAntioxidantmedicine.medical_treatmentLymphocyteMitochondrionmedicine.disease_causePolymerase Chain ReactionPathogenesisVitamin Eoxidative stressLymphocytesaconitase (aconitate hydratase)Aconitate Hydratasereactive oxygen speciesGeneral NeuroscienceACO2General MedicineAlzheimer's diseasemitochondriaPsychiatry and Mental healthClinical Psychologyantioxidantsmedicine.anatomical_structureDisease ProgressionSettore MED/26 - NeurologiaFemaleAlzheimer diseaseAlzheimer's diseaseAzheimer diseasereactive nitrogen speciemedicine.medical_specialtyaconitase (aconitate hydratase); Alzheimer disease; antioxidants; free radicals; lymphocyte; mild cognitive impairment; mitochondria; oxidative stress; reactive nitrogen species; reactive oxygen speciesBlotting Westernfree radicalslymphocytemild cognitive impairmentInternal medicinemedicineHumansCognitive DysfunctionRNA MessengerAgedfree radicaloxidative strebusiness.industryVitamin EAconitasimedicine.diseasereactive nitrogen speciesEndocrinologyGeriatrics and GerontologyAlzheimer's disease; Aconitasi; oxidative stress; Aconitase (aconitate hydratase) Azheimer disease antioxidants free radicals lymphocyte mild cognitive impairment mitochondria oxidative stress reactive nitrogen species reactive oxygen speciesMental Status SchedulebusinessBiomarkersOxidative stressJournal of Alzheimer's Disease
researchProduct

A second family with familial AD and the V717L APP mutation has a later age at onset

2006

Four mutations have been reported at the 717 codon of the amyloid precursor protein (APP), with valine substituted by isoleucine, glycine, phenylalanine, and leucine. While several families with the isoleucine substitution have been described, the other substitutions have been reported in only one family each worldwide. A family with the V717L APP mutation has been previously reported,1 with a mean age at onset of 38 years (range 35 to 39), based on four affected family members, and a mean age at death of 46 years (range 40 to 50). We have identified a second family with a later mean age at onset of 50 years (range 48 to 57) and mean age at death of 61 years (range 57 to 68). Family 171 is …

MalePediatricsmedicine.medical_specialtyMutation Missensemedicine.disease_causeAmyloid beta-Protein PrecursorAlzheimer DiseaseValineInternal medicinemedicineAmyloid precursor proteinHumansAge of OnsetAgedAge of Onset Aged Alzheimer Disease/genetics Alzheimer Disease/physiopathology Amino Acid Substitution Amyloid beta-Protein Precursor/genetics Female Humans Malle Middle Aged Mutation Missense PedigreeMutationSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicabiologyMean ageMiddle AgedPedigreeEndocrinologyAmino Acid Substitutionbiology.proteinFemaleNeurology (clinical)IsoleucineNeurology
researchProduct

Preclinical dementia: an Italian multicentre study on amnestic mild cognitive impairment

2006

&lt;i&gt;Background:&lt;/i&gt; Different rates and cognitive predictors of conversion to dementia have been reported in subjects with different kinds of mild cognitive impairment (MCI). &lt;i&gt;Methods:&lt;/i&gt; A prospective, 24-month follow-up study, involving 269 subjects who strictly fulfilled criteria for the amnestic MCI. &lt;i&gt;Results:&lt;/i&gt; Conversion rate to dementia was 21.4% per year. Seventy-nine out of the 83 individuals who developed dementia were affected by probable Alzheimer’s disease (AD). Among others, at the 24-month follow-up 24.1% were still affected by amnestic MCI, 13.3% had changed their neuropsychological profile of impairment and 17.2% were cognitively no…

Malemedicine.medical_specialtyClinical Dementia RatingCognitive NeuroscienceAudiologyPattern RecognitionNeuropsychological TestsCohort StudiesAlzheimer DiseasePredictive Value of TestsAlzheimer's disease Dementia Mild cognitive impairment NeurospychologymedicineDementiaMemory impairmentHumansMemory disorderProspective StudiesPsychiatryHumans; Alzheimer Disease; Disease Progression; Aged; Predictive Value of Tests; Cognition Disorders; Italy; Verbal Learning; Prospective Studies; Pattern Recognition Visual; Cohort Studies; Follow-Up Studies; Dementia; Neuropsychological Tests; Amnesia; Female; MaleAgedAlzheimer’s disease Mild cognitive impairment Dementia NeurospychologyCognitive disorderNeuropsychologyMild cognitive impairmentCognitionVerbal LearningAlzheimer's diseaseNeurospychologymedicine.diseasePsychiatry and Mental healthPattern Recognition VisualItalyDisease ProgressionFemaleSettore MED/26 - NeurologiaDementiaAmnesiaGeriatrics and GerontologyAlzheimer's diseasePsychologyCognition DisordersVisualFollow-Up Studies
researchProduct

Movements Execution in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

2007

We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer’s Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunct…

Malemedicine.medical_specialtyMild Cognitive ImpairmentMotor dysfunctionneuropsychologyNeurosciences. Biological psychiatry. NeuropsychiatryDiseaseAudiologyNeuropsychological TestsMotor behaviourSeverity of Illness Indexbehavioral disciplines and activitiesAlzheimer Diseasemental disordersmedicineReaction TimeHumansBiomechanicsClinical NoteAlzheimer’s DiseaseCognitive impairmentalzheimer's disease mild cognitive impairment kinematicsAgedDemographypointingMovement DisordersNeuropsychologyCognitionGeneral MedicineControl subjectsBiomechanical PhenomenaSeverity of Illness Index; Humans; Alzheimer Disease; Aged; Mental Recall; Cognition Disorders; Demography; Movement Disorders; Neuropsychological Tests; Amnesia; Biomechanics; Female; Male; Reaction TimeNeuropsychology and Physiological PsychologyNeurologykinematicsMental RecallSettore MED/26 - NeurologiaFemaleNeurology (clinical)AmnesiaPsychologyCognition DisordersNeuroscienceMovement planningRC321-571Behavioural Neurology
researchProduct