Search results for " Animal"
showing 10 items of 3438 documents
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
2015
Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However…
Relationship between inbreeding and milk production traits in two Italian dairy sheep breeds.
2022
The effects of inbreeding in livestock species breeds have been well documented and they have a negative impact on profitability. The objective of this study was to evaluate the levels of inbreeding in Sarda (SAR, n = 785) and Valle del Belice (VdB, n = 473) dairy sheep breeds and their impact on milk production traits. Two inbreeding coefficients (F) were estimated: using pedigree (FPED), or runs of homozygosity (ROH; FROH) at different minimum ROH lengths and different ROH classes. After the quality control, 38,779 single nucleotide polymorphisms remained for further analyses. A mixed-linear model was used to evaluate the impact of inbreeding coefficients on production traits within each …
Incorporación de elementos traza en conchas de melanopsis durante el crecimiento : posibilidades de aplicación en paleoecología
1988
El objetivo del presente trabajo está encaminado al estudio de las variaciones de oligoelementos en la concha de un gasterópodo de agua dulce del género Melanopsis (U dufouri (FERUSSAC), con dos morfotipos) y si éstas tienen que ver, o no, con la fluctuación de una serie de parámetros ambientales. La importancia del trabajo radica en la posibilidad de la aplicación paleoecológica de sus resultados, ya que el género MelanopsÍs tiene un abundante registro fósil durante todo el Cenozoico. La incorporación de oligoelementos se efectúa a medida que la concha va creciendo por acreción; lo ideal sería que tal crecimiento fuera circadiano, ya que se podría seguir día a día, sobre la concha, la fluc…
Vocal communication in the Iberian wolf
2015
PARTE I. COMUNICACIÓN ACÚSTICA EN EL LOBO IBÉRICO El lobo (Canis lupus) es un carnívoro social cuya unidad básica de organización social es la manada, formada básicamente por una pareja reproductora y sus descendientes de varios años (Mech 1970, 1999). El número medio de lobos que integra una manada (tamaño de grupo) oscila entre 3 y 11 individuos (Fuller et al., 2003) y, en condiciones naturales, depende en gran medida de la disponibilidad de alimento (Mech & Boitani, 2003). Uno de los comportamientos más característicos y llamativos de los lobos es la emisión de aullidos para comunicarse a largas distancias. Quizá por este motivo la comunicación acústica de los lobos ha sido objeto de est…
Enonciation animale : Franz Kafka, Primo Levi, le singe et la poule
2018
Cet articleessayera de discuter la question de l’énonciation animale à partir d’une perspective de recherche un peu plus étendue : celle qu’on a appelée d’une zoosemiotique 2.0 : c’est à dire une perspective sémiotique que, en outrepassant les recherches traditionnelles sur le langage et/ou la communication animale (inscrites dans une épistémologie naturaliste et scientiste), peut étudier l’animal ‘en situation’, acteur non-humain qui a des relations sociales (narrative, discursives) avec d’autres acteurs humaines et non humains. Plutôt que présupposer une différence de principe entre homme et animales, il faudrait donc rétablir les dispositifs sémiotiques à partir desquels ils se construis…
Per favore, non chiamatelo cibo per cani
2017
Fra uomo e cane esiste quello che potremmo chiamare un patto nutrizionale, un accordo del tutto implicito che, per tramite del cibo, li lega. Come fare allora a conoscere i termini di tale patto? Come ricostruire le tante potenziali logiche che possono governarlo? Come capire insomma cosa può essere un cane per una persona e viceversa? Due modi di affrontare la questione sono evidentemente quelli dell’etologia e dell’antropologia, che cercano di risolvere il problema da un lato guardando agli animali, al modo in cui si comportano e imparano, capiscono e si esprimono, dall’altro alle comunità umane, e al ruolo che di volta in volta queste creature assumono al loro interno. L’approccio semiot…
Zoosemiotica 2.0. Forme e politiche dell'animalità
2017
Questo volume ha tre direzioni di discorso. Innanzitutto, un dialogo fra la semiotica e le altre discipline interessate agli studi animali: la filosofia, la filosofia del linguaggio e della mente, le scienze umane e sociali, le scienze cognitive e le neuroscienze. Non a caso molti degli interventi contenuti in questo volume non sono di semiologi ma di filosofi, sociologi, antropologi, linguisti, filologi, letterati etc. In secondo luogo, una discussione interna alla semiotica, nel passaggio dalla zoosemiotica 1.0 (tradizionalmente più interessata ai linguaggi e alle forme di comunicazione delle diverse specie animali) alla zoosemiotica 2.0, di conserva con altri settori a prima vista oppost…
Sex Allocation Theory for Facultatively Sexual Organisms Inhabiting Seasonal Environments: The Importance of Bet Hedging
2018
Adaptive explanations for dormancy often invoke bet hedging, where reduced mean fitness can be adaptive if it associates with reduced fitness variance. Sex allocation theory typically ignores variance effects and focuses on mean fitness. For many cyclical parthenogens, these themes become linked, as only sexually produced eggs undergo the dormancy needed to survive harsh conditions. We ask how sex allocation and the timing of sex evolve when this constraint exists in the form of a trade-off between asexual reproduction and sexual production of dormant eggs—the former being crucial for within-season success and the latter for survival across seasons. We show that male production can be tempo…