Search results for " Applications"
showing 10 items of 4541 documents
Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker
2020
In recent years, the idea that sleep is critical for cognitive processing has gained strength. Alzheimer’s disease (AD) is the most common form of dementia worldwide and presents a high prevalence of sleep disturbances. However, it is difficult to establish causal relations, since a vicious circle emerges between different aspects of the disease. Nowadays, we know that sleep is crucial to consolidate memory and to remove the excess of beta-amyloid and hyperphosphorilated tau accumulated in AD patients’ brains. In this review, we discuss how sleep disturbances often precede in years some pathological traits, as well as cognitive decline, in AD. We describe the relevance of sleep to memory co…
New-stage discharge relationships for free and submerged sluice gates
2012
Abstract The flow movement through a sluice gate is investigated for both free and submerged flow conditions. For free flow condition, the current dimensionless formula, indicated acceptable accuracy; while for submerged flow condition it was modified especially for low submerged condition. In this regard, Buckingham theorem along with the Incomplete Self-Similarity concept was employed and a new stage–discharge relationship was developed accordingly. Also, to achieve a suitable formula for submerged flow condition being accurate in low submergence, the maximum tailwater depth allowing the free flow condition and head loss factor were identified as missing parameters in the functional dimen…
New stage-discharge relationship for cylindrical and semi-cylindrical edged sluice gates
2019
Abstract Gates are simple hydraulic structures which have been widely used for flow control and measurement in irrigation networks. In this paper new sluice gates with cylindrical and semi-cylindrical edges were introduced and the flow movement below these types of gates was experimentally investigated for both free- and submerged-flow conditions. The Buckingham theorem of dimensional analysis and the self-similarity theory were applied for developing the stage-discharge relationships for the two investigated flow conditions. For these cylindrical and semi-cylindrical edged gates and a free-flow condition, the proposed stage-discharge relationship was characterized by an estimate error less…
proTRAC - a software for probabilistic piRNA cluster detection, visualization and analysis
2012
Abstract Background Throughout the metazoan lineage, typically gonadal expressed Piwi proteins and their guiding piRNAs (~26-32nt in length) form a protective mechanism of RNA interference directed against the propagation of transposable elements (TEs). Most piRNAs are generated from genomic piRNA clusters. Annotation of experimentally obtained piRNAs from small RNA/cDNA-libraries and detection of genomic piRNA clusters are crucial for a thorough understanding of the still enigmatic piRNA pathway, especially in an evolutionary context. Currently, detection of piRNA clusters relies on bioinformatics rather than detection and sequencing of primary piRNA cluster transcripts and the stringency …
GSWABE: faster GPU-accelerated sequence alignment with optimal alignment retrieval for short DNA sequences
2014
In this paper, we present GSWABE, a graphics processing unit GPU-accelerated pairwise sequence alignment algorithm for a collection of short DNA sequences. This algorithm supports all-to-all pairwise global, semi-global and local alignment, and retrieves optimal alignments on Compute Unified Device Architecture CUDA-enabled GPUs. All of the three alignment types are based on dynamic programming and share almost the same computational pattern. Thus, we have investigated a general tile-based approach to facilitating fast alignment by deeply exploring the powerful compute capability of CUDA-enabled GPUs. The performance of GSWABE has been evaluated on a Kepler-based Tesla K40 GPU using a varie…
Virtual Reality as a Medium to Elicit Empathy: A Meta-Analysis.
2020
The current meta-analysis aims to investigate and clarify existing research on virtual reality (VR) as a medium to elicit empathy. An exhaustive literature search (updated to February 29, 2020) enabled us to locate seven published articles, yielding a total of nine independent samples. The results reveal statistically significant positive changes in perspective-taking outcomes after VR exposure (
Sosiaalialan asiakastietojärjestelmissä paljon parannettavaa: käyttäjäkokemukset 2019
2020
Sosiaali- ja terveydenhuollon digitalisaatiolle on asetettu paljon odotuksia niin palveluiden laadun, saavutettavuuden kuin tehokkuuden osalta. Asiakas- ja potilastietojärjestelmiltä odotetaan paljon tavoitteiden saavuttamiseksi. Asiakastietojärjestelmät ovat laajasti käytössä sosiaalialalla, mutta niiden käyttöä työvälineenä ja niiden avulla saavutettuja hyötyjä on tutkittu ammattilaisten näkökulmasta vain vähän. Keväällä 2019 kartoitettiin ensimmäistä kertaa valtakunnallisesti sosiaalialan ammattilaisten käyttäjäkokemuksia asiakastietojärjestelmistä. Tässä artikkelissa kuvataan kyselytutkimuksen toteutus ja tulokset eniten käytettyjen tuotemerkkien osalta. Tutkimus toimii pilottina vuonna…
What drives passion? An empirical examination on the impact of personality trait interactions and job environments on work passion
2022
Passionate employees are essential for organisational success as they foster higher performance and exhibit lower turnover or absenteeism. While a large body of research has investigated the consequences of passion, we know only little about its antecedents. Integrating trait interaction theory with trait activation theory, this paper examines how personality traits, i.e. conscientiousness, agreeableness, and neuroticism impact passion at work across different job situations. Passion has been conceptualized as a two-dimensional construct, consisting of harmonious work passion (HWP) and obsessive work passion (OWP). Our study is based on a sample of N = 824 participants from the myPersonalit…
Using random networks to study the dynamics of respiratory syncytial virus (RSV) in the Spanish region of Valencia
2011
[EN] Seasonal fluctuations in the incidence of several respiratory infections are a feature of epidemiological surveys all around the world. This phenomenon is characteristic of influenza and respiratory syncytial virus pandemics. However, the explanation of the seasonal outbreaks of these diseases remains poorly understood. Many statistical studies have been carried out in order to provide a correlation of the outbreaks with climatic or social factors without achieving a definitive conclusion. Here we show that, in a random social network, self-sustained seasonal epidemics emerge as a process modulated by the infection probability and the immunity period after recovering from the infection…
Social network loyalty: evaluating the role of attitude, perceived risk and satisfaction
2013
PurposeThe aim of this paper is to analyse the determinants of social networking site loyalty, paying special attention to the roles of user attitude, perceived risk and satisfaction.Design/methodology/approachThe impact of uses and gratifications of social networking sites, attitude, perceived risks and satisfaction on social networking site loyalty is tested through structural equation modelling techniques. The sample consisted of 811 Spanish social networking site users collected through a personal survey. Risk is measured as a formative construct.FindingsData analysis shows that attitude is a key variable in increasing satisfaction and loyalty towards social networking sites. Sociabilit…