Search results for " Applications"
showing 10 items of 4541 documents
Increasing stability in the linearized inverse Schrödinger potential problem with power type nonlinearities
2022
We consider increasing stability in the inverse Schr\"{o}dinger potential problem with power type nonlinearities at a large wavenumber. Two linearization approaches, with respect to small boundary data and small potential function, are proposed and their performance on the inverse Schr\"{o}dinger potential problem is investigated. It can be observed that higher order linearization for small boundary data can provide an increasing stability for an arbitrary power type nonlinearity term if the wavenumber is chosen large. Meanwhile, linearization with respect to the potential function leads to increasing stability for a quadratic nonlinearity term, which highlights the advantage of nonlinearit…
Oncogenic BRAF and p53 Interplay in Melanoma Cells and the Effects of the HDAC Inhibitor ITF2357 (Givinostat)
2023
Oncogenic BRAF mutations have been widely described in melanomas and promote tumour progression and chemoresistance. We previously provided evidence that the HDAC inhibitor ITF2357 (Givinostat) targets oncogenic BRAF in SK-MEL-28 and A375 melanoma cells. Here, we show that oncogenic BRAF localises to the nucleus of these cells, and the compound decreases BRAF levels in both the nuclear and cytosolic compartments. Although mutations in the tumour suppressor p53 gene are not equally frequent in melanomas compared to BRAF, the functional impairment of the p53 pathway may also contribute to melanoma development and aggressiveness. To understand whether oncogenic BRAF and p53 may cooperate, a po…
Monotone generalized nonlinear contractions and fixed point theorems in ordered metric spaces
2011
The purpose of this paper is to present some fixed point theorems for T -weakly isotone increasing mappings which satisfy a generalized nonlinear contractive condition in complete ordered metric spaces. As application, we establish an existence theorem for a solution of some integral equations.
Enabling Energy Savings in Offshore Mechatronic Systems by using Self-Contained Cylinders
2019
This paper proposes a novel actuation system for an offshore drilling application. It consists of three self-contained electro-hydraulic cylinders that can share and store regenerated energy. The energy saving potential of the proposed solution is analyzed through a multibody system simulation. The self-contained system demonstrates superior energy efficiency compared to the benchmark system representing the state-of-the-art approach used today (i.e., valve-controlled cylinders by means of pressure-compensated directional control valves and counter-balance valves, supplied by a centralized hydraulic power unit). Due to the power on demand capability, the cancellation of the throttling losse…
Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEM) of a Customized Stent-Graft for Endovascular (EVAR) Treatment of Abdominal Aorti…
2023
Background: The treatment of abdominal aortic aneurysm (AAA) is today commonly treated by inserting a stent-graft by the endovascular route, without resorting to open surgery. However, some clinical cases do not allow this less invasive approach, meaning that the stent-graft cannot be inserted and open surgery is used. Methods: In the study, we propose a fluid–structure interaction (FSI) analysis of an aneurysmatic aorta that could not be treated with Endovascular Aneurysm Repair (EVAR). The vessel is reconstructed through segmentation from CT scans and subsequently modeled on CAD software to create the surface and thickness of the vessel itself. Subsequently, we proceeded to carry out Comp…
Iterative Learning Applied to Hydraulic Pressure Control
2018
This paper addresses a performance limiting phenomenon that may occur in the pressure control of hydraulic actuators subjected to external velocity disturbances. It is demonstrated that under certain conditions a severe peaking of the control error may be observed that significantly degrades the performance of the system due to the presence of nonlinearities. The phenomenon is investigated numerically and experimentally using a system that requires pressure control of two hydraulic cylinders. It is demonstrated that the common solution of feed forwarding the velocity disturbance is not effective in reducing the peaking that occurs as a result of this phenomenon. To improve the system perfor…
Trening metaleksykograficzny w globalnej rzeczywistości online - praktyczna pomoc czy archaizm w międzykulturowym procesie glottodydaktycznym XXI wie…
2020
In this article, its author offers the practical considerations of a philologist, a linguist, a translation-studies researcher, and an eager modern-language academic teacher, regarding a rangę of contemporary technological solutions/tools for enhancing the acąuisition of a foreign language (English). In particular, the author refers to electronic pedagogical dictionaries - the monolingual Dictionary.com, the bilingual Wielojęzyczny słownik polski OFFLINE, and the semibilingual Słownik angielskiego Diki, which are presently commonly used by young language learners. Such smart-applications developed for smartphones and tablets — in the author’s view — are remarkable tools for enhancing the co…
Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain
2020
This article belongs to the Special Issue Bacteriophage—Molecular Studies.
IoT -based adversarial attack's effect on cloud data platform services in a smart building context
2020
IoT sensors and sensor networks are widely employed in businesses. The common problem is a remarkable number of IoT device transactions are unencrypted. Lack of correctly implemented and robust defense leaves the organization's IoT devices vulnerable to numerous cyber threats, such as adversarial and man-in-the-middle attacks or malware infections. A perpetrator can utilize adversarial examples when attacking machine learning (ML) models, such as convolutional neural networks (CNN) or deep neural networks (DNN) used, e.g., in DaaS cloud data platform service of smart buildings. DaaS cloud data platform's function in this study is to connect data from multiple IoT sensors, databases, private…
DM-like anomalies in neutron multiplicity spectra
2021
Abstract A new experiment collects data, since November 2019, at a depth of 210 m.w.e. in the Callio Lab in the Pyhasalmi mine in Finland. The setup, called NEMESIS (New Emma MEasurementS Including neutronS), incorporates infrastructure from the EMMA experiment with neutron and large-area plastic scintillator detectors. The experiment’s primary aim is to combine muon tracking with position-sensitive neutron detection to measure precision yields, multiplicities, and lateral distributions of high-multiplicity neutron events induced by cosmic muons in various materials. The data are relevant for background evaluation of the deep-underground searches for Dark Matter (DM), neutrino-less double b…