Search results for " Bases"
showing 10 items of 272 documents
Reactome graph database: Efficient access to complex pathway data
2018
Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. One of its main priorities is to provide easy and efficient access to its high quality curated data. At present, biological pathway databases typically store their contents in relational databases. This limits access efficiency because there are performance issues associated with queries traversing highly interconnected data. The same data in a graph database can be queried more efficiently. Here we present the rationale behind the adoption of a graph database (Neo4j) as well as the new ContentService (REST API) that provides access to these data. The Neo4j graph database and its qu…
Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures
2020
G-quadruplexes are four-stranded helical nucleic acid structures formed by guanine-rich sequences. A considerable number of studies have revealed that these noncanonical structural motifs are widespread throughout the genome and transcriptome of numerous organisms, including humans. In particular, G-quadruplexes occupy strategic locations in genomic DNA and both coding and noncoding RNA molecules, being involved in many essential cellular and organismal functions. In this review, we first outline the fundamental structural features of G-quadruplexes and then focus on the concept that these DNA and RNA structures convey a distinctive layer of epigenetic information that is critical for the c…
Reactome diagram viewer: data structures and strategies to boost performance
2017
Abstract Motivation Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. For web-based pathway visualization, Reactome uses a custom pathway diagram viewer that has been evolved over the past years. Here, we present comprehensive enhancements in usability and performance based on extensive usability testing sessions and technology developments, aiming to optimize the viewer towards the needs of the community. Results The pathway diagram viewer version 3 achieves consistently better performance, loading and rendering of 97% of the diagrams in Reactome in less than 1 s. Combining the multi-layer html5 canvas strategy with a space partit…
E4BP4/NFIL3 modulates the epigenetically repressed RAS effector RASSF8 function through histone methyltransferases
2018
RAS proteins are major human oncogenes, and most of the studies are focused on enzymatic RAS effectors. Recently, nonenzymatic RAS effectors (RASSF, RAS association domain family) have garnered special attention because of their tumor-suppressive properties in contrast to the oncogenic potential of the classical enzymatic RAS effectors. Whereas most members of RASSF family are deregulated by promoter hypermethylation, RASSF8 promoter remains unmethylated in many cancers but the mechanism(s) of its down-regulation remains unknown. Here, we unveil E4BP4 as a critical transcriptional modulator repressing RASSF8 expression through histone methyltransferases, G9a and SUV39H1. In line with these …
WES/WGS Reporting of Mutations from Cardiovascular "Actionable" Genes in Clinical Practice: A Key Role for UMD Knowledgebases in the Era of Big Datab…
2016
International audience; High-throughput next-generation sequencing such as whole-exome and whole-genome sequencing are being rapidly integrated into clinical practice. The use of these techniques leads to the identification of secondary variants for which decisions about the reporting or not to the patient need to be made. The American College of Medical Genetics and Genomics recently published recommendations for the reporting of these variants in clinical practice for 56 "actionable" genes. Among these, seven are involved in Marfan Syndrome And Related Disorders (MSARD) resulting from mutations of the FBN1, TGFBR1 and 2, ACTA2, SMAD3, MYH11 and MYLK genes. Here, we show that mutations col…
Modulating disease-relevant tau oligomeric strains by small molecules
2020
The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, are highly toxic due to their strong ability to seed tau misfolding and propagate the pathology seen across different neurodegenerative diseases. We previously showed that novel curcumin derivatives affect preformed tau oligomer aggregation pathways by promoting the formation of more aggregated and nontoxic tau aggregates. To further investigate their therapeutic potential, we have extended our studies o disease-relevant bra…
ÁCIDOS Y BASES
1994
Audiovisual didáctico que pretende subsanar la falta de práctica de los alumnos de Bachiller en nomenclatura y formulación.
La relación entre las palabras clave aportadas por autores de artículos de revista y su indización en las bases de datos ISOC, IME e ICYT
2005
Se analizan las palabras clave proporcionadas por autores en sus artículos científicos y los descriptores asignados a dichos artículos en varias bases de datos para averiguar el papel que juegan esas palabras clave durante el proceso de indización de los mismos. Para ello, se seleccionaron 108 publicaciones periódicas repartidas proporcionalmente entre Ciencias Sociales y Humanidades (36 revistas), Ciencia y Tecnología (36) y Ciencias Médicas y de la Salud (36). De cada una de las 108 publicaciones se escogieron 10 artículos repartidos entre diferentes años, por lo que se trabajó con un total de 1080 que cumplían dos condiciones: poseer palabras clave y estar indizados en las bases de datos…
Difusion of spanish psychology journals throug national and international bibliographical data bases
2005
Las revistas científicas definen el "research front" de cualquier disciplina académica. Existe una interacción característica entre nivel de desarrollo institucio-nal e implantación social y número y diversidad de revistas. Esto es especialmente claro en el caso de la psicología española. Se estudia la situación actual de las revis-tas españolas de psicología, analizándose algunas de sus características formales como la antigüedad y periodicidad, localidad e institución editora, circulación en ba-ses de datos y accesibilidad, a través de su inclusión en las principales bases de datos bibliográficas, nacionales e internacionales.
Premis, càstigs i educació
2008
Els autors defensen que el costum i la llei confi guren la legalitat i la moralitat socials i determinen el nostre comportament, alhora que qüestionen els resultats 'esperats' de l'aplicació mecànica dels premis i càstigs en educació. Distingeixen el control extern 'supervisió' i l'intern 'motivació' en l'esdevenir dels comportaments analitzats, en relació a l'aplicació d'aquelles sancions i tot seguit aborden l'estudi monogràfi c des del conductisme, des del cognitivisme i des de la perspectiva moral. Ara aborden la complexitat contextual de la intervenció pedagògica i les alternatives possibles des dels plantejaments actitudinals dels subjectes, per concloure que els premis tenen la fi na…